An increase in normetanephrine in hair follicles of acne lesions through the sympatho‐adrenal medullary system in acne patients with anxiety
An increase in normetanephrine in hair follicles of acne lesions through the sympatho‐adrenal medullary system in acne patients with anxiety
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DOI：
10.1111/1346-8138.15935
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发表时间：
2021-05
期刊：
影响因子：
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通讯作者：
K. Mizuno;H. Sakaue;Keita Kohsaka;Hidetomo Takeda;Nobukazu Hayashi;Takashi Sato
中科院分区：
文献类型：
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作者：
K. Mizuno;H. Sakaue;Keita Kohsaka;Hidetomo Takeda;Nobukazu Hayashi;Takashi Sato
寻常痤疮是一种慢性炎症性皮肤病，不仅与皮脂腺功能紊乱有关，还与各种内源性和外源性应激有关。由于皮脂腺受神经内分泌控制，包括下丘脑-垂体-肾上腺轴和神经自分泌机制，目前尚不清楚心理应激与痤疮发病机制的关系。本研究对18例轻、中度痤疮患者的心理应激与痤疮皮损中儿茶酚胺的关系进行了研究。状态-特质焦虑量表（STAI）显示，所有患者都焦虑，其中6人焦虑程度较低，12人焦虑程度较高。唾液α-淀粉酶活性（sAA）受交感肾上腺髓质（SAM）系统调节，与STAI状态焦虑评分（STAI-S）呈正相关，并且在焦虑程度高而不是低的痤疮患者中显著检测到。此外，痤疮皮损毛囊中的normetaneline（而非metaneline）（两者均为儿茶酚胺代谢物）水平也与STAI-S呈正相关。此外，高焦虑患者的normetaneline水平高于低焦虑患者，而痤疮皮损毛囊中的metaneline没有变化。此外，无论是sAA，也没有metaneketin和normetaneketin的痤疮病变与痤疮的严重程度的患者。因此，这些结果提供了新的证据，即SAM系统相关的毛囊中normetaneline水平的增加参与焦虑患者的痤疮病理学。
Acne vulgaris, a chronic inflammatory skin disease, has been associated with not only sebaceous gland dysfunction but also various endogenous and exogenous stresses. Since sebaceous glands are under neuroendocrine control, including the hypothalamic–pituitary–adrenal axis and neuro‐autocrine mechanisms, it remains unclear how psychological stress relates to the pathogenesis of acne. In this study, we investigated the relationship between psychological stress and catecholamine in acne lesions from 18 patients with mild or moderate acne. The State‐Trait Anxiety Inventory (STAI) revealed that all patients were anxious, with six having low anxiety and 12 high anxiety. Salivary α‐amylase activity (sAA), which is regulated by the sympatho‐adrenal medullary (SAM) system, positively correlated with the STAI State Anxiety scores (STAI‐S) and was significantly detectable in acne patients with high rather than low anxiety. In addition, the level of normetanephrine, but not metanephrine, both of which are catecholamine metabolites, in hair follicles of acne lesions also positively correlated with the STAI‐S. Furthermore, the normetanephrine level was higher in patients with high rather than low anxiety, whereas there was no change in metanephrine in the hair follicles of the acne lesions. Moreover, neither the sAA nor metanephrine and normetanephrine in the acne lesions was related to acne severity in the patients. Thus, these results provide novel evidence that a SAM system‐associated increase of normetanephrine level in hair follicles is involved in the acne pathology of patients with anxiety.