Modification of ventricular fibrillation latency following coronary artery occlusion in the conscious pig.
Modification of ventricular fibrillation latency following coronary artery occlusion in the conscious pig.
复制标题
清醒猪冠状动脉闭塞后心室颤动潜伏期的改变。
作者：
J. E. Skinner;J. Lie;M. L. Entmian
在45只未麻醉的农场猪上进行冠状动脉左前降支的突然闭塞，以评价1）动物对实验室的适应和2）普萘洛尔的β受体阻滞对室颤（VFL）潜伏期的相对影响。与对照值相比，VFL大大延长（即，VF延迟或预防）的适应（P小于0.01），缩短了大剂量（2毫克/公斤）的外消旋普萘洛尔在不适应的动物（P小于0.02），并再次增加，而在药物的影响下，适应（P小于0.051）。较低剂量（0.02 mg/kg）的外消旋普萘洛尔、2 mg/kg的右旋普萘洛尔和较高心率的心室起搏均对VFL无影响。结果表明，减少心理压力是非常有效的延迟或预防VF的发作，低剂量的普萘洛尔是无效的，和更高的剂量是有害的不适应的动物。
Abrupt occlusion of the left anterior descending coronary artery was performed on 45 unanesthetized farm pigs in order to evaluate the relative effects on the latency to ventricular fibrillation (VFL) of 1) adaptation of the animals to the laboratory, and 2) beta-receptor blockade by propranolol. Compared to control values, VFL was greatly lengthened (i.e., VF delayed or prevented) by adaptation (P smaller than 0.01), was shortened by large (2 MG/KG) doses of racemic propranolol in unadapted animals (P smaller than 0.02), and was again increased while under the influence of the drug, by adaptation (P smaller than 0.051). Neither a lower (0.02 mg/kg) dose of racemic propranolol, 2 mg/kg of dextropropranolol, nor ventricular pacing to a higher heart rate had an effect on VFL. The results suggest that reduced psychological stress was very effective in retarding or preventing the onset of VF, that low doses of propranolol were ineffective, and that higher doses were deleterious in unadapted animals.