Serum interleukin-18 levels are elevated in schizophrenia
Serum interleukin-18 levels are elevated in schizophrenia
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DOI：
10.1016/s0165-1781(00)00196-7
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发表时间：
2000-09-25
影响因子：
11.3
通讯作者：
Asai, M
中科院分区：
文献类型：
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作者：
Tanaka, KF;Shintani, F;Asai, M
白细胞介素 18 (IL-18) 是最近发现的一种促炎细胞因子，在辅助性 T 细胞 1 (Th1) 反应中发挥关键作用。 IL-18 由巨噬细胞样细胞产生，已知 IL-18 的不适当产生与免疫紊乱有关。精神分裂症是一种常见病，其发病机制尚不清楚。然而，包括Th1细胞因子反应在内的炎症反应系统的激活可能与精神分裂症的病理生理学有关。我们使用 ELISA 测定法测量了 66 名精神分裂症患者以及年龄和性别匹配的对照受试者的血清 IL-18 水平。我们发现精神分裂症患者血清 IL-18 水平显着升高（P = 0.0002）。这一发现支持了免疫激活参与精神分裂症病理生理学的假设。 (C) 2000 Elsevier Science Ireland Ltd. 保留所有权利。
Interleukin-18 (IL-18) is a recently discovered proinflammatory cytokine which plays a pivotal role in T helper 1 (Th1) responses. IL-18 is produced by macrophage-like cells, and inappropriate IL-18 production has been known to be involved in immunological disturbances. Schizophrenia is a common disease whose pathogenesis is still unclear; however, an activation of the inflammatory response system, including the Th1 cytokine response, may be related to the pathophysiology of schizophrenia. We measured the serum IL-18 levels of 66 schizophrenics and age- and sex-matched control subjects by using an ELISA assay. We found significantly increased serum IL-18 levels in the schizophrenic patients (P = 0.0002). This finding supports the hypothesis that immune activation is involved in the pathophysiology of schizophrenia. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.