Functional Correlates of Plasma Renin Activity in Hypertensive Patients
Functional Correlates of Plasma Renin Activity in Hypertensive Patients
复制标题
高血压患者血浆肾素活性的功能相关性
DOI：
10.1161/01.cir.41.3.555
复制
发表时间：
1970
期刊：
影响因子：
37.8
通讯作者：
E. Frohlich
中科院分区：
文献类型：
--
作者：
H. Dustan;R. Tarazi;E. Frohlich
本文对31例正常血压者和93例未经治疗的高血压患者的外周血浆肾素活性进行了相关性研究。后者根据高血压的表观类型分为：原发性（58），肾血管性（21），肾实质疾病（11）和原发性醛固酮增多症（3）。在正常男性、原发性高血压男性和肾动脉狭窄患者中，血浆肾素活性与总血容量和血浆容量呈负相关;在正常和原发性高血压女性和肾实质疾病患者中未发现相关性。血清钠和钾浓度显着负相关的肾素活性，只有在肾血管性高血压，而不是在其他高血压或正常组。本文研究了高血压病患者血浆肾素活性与动脉压及其他血流动力学指标的关系。只有在肾血管性组舒张压呈正相关且显著，表明肾升压系统参与了这种形式的高血压，在很宽的压力范围内。心脏指数和左室射血率与原发性高血压男性和肾动脉及实质疾病患者的肾素活性直接相关。这些数据表明，高血压患者的血浆肾素活性不应单独判断，而应沿着与改变它的因素一起判断。
Correlates of peripheral plasma renin activity were studied in 31 normotensive subjects and 93 untreated hypertensive patients. The latter were grouped according to apparent type of hypertension: essential (58), renovascular (21), renal parenchymal disease (11), and primary aldosteronism (3). Plasma renin activity was inversely correlated with total blood and plasma volumes in normal men, men with essential hypertension, and patients with renal arterial stenosis; no correlations were found in normal and essential hypertensive women and patients with renal parenchymal disease. Serum sodium and potassium concentrations were significantly and inversely related to renin activity only in renovascular hypertension and not in the other hypertensive or normal groups. Relationships of plasma renin activity to arterial pressure and other hemodynamic functions were studied in hypertensive patients. Only in the renovascular group did diastolic pressure correlate positively and significantly, indicating participaton of the renal pressor system in this form of hypertension throughout a wide range of pressures. Cardiac index and left ventricular ejection rate were directly related to renin activity in essential hypertensive men and patients with renal arterial and parenchymal diseases. The data show that plasma renin activity in hypertensive patients should not be judged alone but along with factors modifying it.