SALINOMYCIN - NEW MONOVALENT CATION IONOPHORE
SALINOMYCIN - NEW MONOVALENT CATION IONOPHORE
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DOI：
10.1016/0006-291x(75)90490-8
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发表时间：
1975-01-01
影响因子：
3.1
通讯作者：
MIYAZAKI, Y
中科院分区：
文献类型：
--
作者：
MITANI, M;YAMANISHI, T;MIYAZAKI, Y
通过测定盐霉素及其衍生物与阳离子的络合能力和阳离子在有机相中的迁移速率，研究了盐霉素及其衍生物的阳离子识别。盐霉素在两相体系中表现出对K+的优先选择性。抗生素对Na+、Rb+和K+跨CCl 4体相迁移的影响与K+相当，但对Cs+、Mg ~（2+）、Ca ~（2+）、Sr ~（2+）的跨CCl 4体相迁移无影响。从以上结果可以得出盐霉素作为碱离子载体的结论。OH-酰化盐霉素保留了母体化合物的活性，但COOH-酯化盐霉素失去了活性。
The cation discriminations of salinomycin and its derivatives have been studied by measuring complexability with cations and transport rate of them across organic phase. Salinomycin exhibited a great preference for K+over other monovalent and divalent cations in migrating cations into organic phase in two phase systems. The antibiotic mediated the transport of Na+and Rb+as effectively as that of K+across CCl4bulk phase, but not those of Cs+, Mg2+, Ca2+, Sr2+. From the above results, salinomycin is concluded to act as an alkali ion carrier. The OH-acylated salinomycins retained the activity of parent compound, but the COOH-esterified salinomycins lost the activity.