Combined effect of sesamin and α-lipoic acid on hepatic fatty acid metabolism in rats
Combined effect of sesamin and α-lipoic acid on hepatic fatty acid metabolism in rats
复制标题
DOI：
10.1007/s00394-012-0408-3
复制
发表时间：
2013-04-01
影响因子：
5
通讯作者：
Nakajima, Chihiro
中科院分区：
文献类型：
--
作者：
Ide, Takashi;Azechi, Ayana;Nakajima, Chihiro
饲粮芝麻素（芝麻素与皂苷1:1混合）可减少大鼠肝脏脂肪酸合成，但增加脂肪酸氧化。膳食α -硫辛酸降低肝脏脂肪酸合成。这些变化可以解释芝麻素和α -硫辛酸的降血脂作用。预计这些化合物在饮食中的组合可能比单独的化合物更能改善脂质代谢。因此，我们研究了芝麻素和α -硫辛酸对大鼠脂质代谢的联合影响。雄性Sprague-Dawley大鼠分别在饲粮中添加0或2 g/kg芝麻素和0或2.5 g/kg α -硫辛酸，饲喂22 d。芝麻素和α -硫辛酸降低了血清脂质浓度，这些化合物的组合进一步降低了这些参数。这些化合物降低了甘油三酯的肝脏浓度，木脂素在降低该值方面效果较差。联合用药未能引起肝甘油三酯浓度的较大幅度下降。芝麻素和α -硫辛酸组合以添加方式降低肝脏脂肪生成酶活性和mRNA水平。芝麻素显著提高肝脏脂肪酸氧化酶的各项指标。α -硫辛酸通过降低肝脏中某些脂肪酸氧化酶的活性和肉毒碱浓度来拮抗芝麻素对脂肪酸氧化的刺激作用。这可能解释了在给予含有芝麻素和α -硫辛酸的饮食的大鼠中，没有观察到肝甘油三酯浓度的显著降低。
Dietary sesamin (1:1 mixture of sesamin and episesamin) decreases fatty acid synthesis but increases fatty acid oxidation in rat liver. Dietary alpha-lipoic acid lowers hepatic fatty acid synthesis. These changes can account for the serum lipid-lowering effect of sesamin and alpha-lipoic acid. It is expected that the combination of these compounds in the diet potentially ameliorates lipid metabolism more than the individual compounds. We therefore studied the combined effect of sesamin and alpha-lipoic acid on lipid metabolism in rats.Male Sprague-Dawley rats were fed diets supplemented with 0 or 2 g/kg sesamin and containing 0 or 2.5 g/kg alpha-lipoic acid for 22 days.Sesamin and alpha-lipoic acid decreased serum lipid concentrations and the combination of these compounds further decreased the parameters in an additive fashion. These compounds reduced the hepatic concentration of triacylglycerol, the lignan being less effective in decreasing this value. The combination failed to cause a stronger decrease in hepatic triacylglycerol concentration. The combination of sesamin and alpha-lipoic acid decreased the activity and mRNA levels of hepatic lipogenic enzymes in an additive fashion. Sesamin strongly increased the parameters of hepatic fatty acid oxidation enzymes. alpha-Lipoic acid antagonized the stimulating effect of sesamin of fatty acid oxidation through reductions in the activity of some fatty acid oxidation enzymes and carnitine concentration in the liver. This may account for the failure to observe strong reductions in hepatic triacylglycerol concentration in rats given a diet containing both sesamin and alpha-lipoic acid.