Separate MRI Quantification of Dispersed (Ferritin-like) and Aggregated (Hemosiderin-like) Storage Iron
Separate MRI Quantification of Dispersed (Ferritin-like) and Aggregated (Hemosiderin-like) Storage Iron
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DOI：
10.1002/mrm.22273
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发表时间：
2010-05-01
影响因子：
3.3
通讯作者：
Brittenham, Gary M.
中科院分区：
文献类型：
--
作者：
Jensen, Jens H.;Tang, Haiying;Brittenham, Gary M.
提出了一种新的MRI方法，用于分别量化组织储存（非血红素）铁的两种主要形式：铁蛋白铁，一种可以快速动员的分散的可溶性部分，和含铁血黄素铁，一种聚集的不溶性部分，作为长期储备。该方法利用多个自旋回波序列，利用事实上，聚集的铁可以诱导多个自旋回波序列的非单指数信号衰减。该方法是在体外验证琼脂糖phantomy，模拟分散的铁与氯化锰，和聚集的铁与氧化铁微球。为了证明人体研究的可行性，初步的体内数据，从两个健康对照组和六名患者输血铁超载。对于体模和人类受试者，还测量了常规R（2）和R（2）* 弛豫速率，以将所提出的方法与已建立的MRI铁定量技术进行对比。分散（铁蛋白样）铁的定量可能提供一种新的手段，监测铁超载患者的铁诱导毒性的风险，并与聚集（含铁血黄素样）铁的定量，提高总储存铁估计的准确性。Magn Reson Med 63：1201-1209，2010. (C)2010 Wiley-Liss，Inc.
A new MRI method is proposed for separately quantifying the two principal forms of tissue storage (nonheme) iron: ferritin iron, a dispersed, soluble fraction that can be rapidly mobilized, and hemosiderin iron, an aggregated, insoluble fraction that serves as a long-term reserve. The method utilizes multiple spin echo sequences, exploiting the fact that aggregated iron can induce nonmonoexponential signal decay for multiple spin echo sequences. The method is validated in vitro for agarose phantoms, simulating dispersed iron with manganese chloride, and aggregated iron with iron oxide microspheres. To demonstrate feasibility for human studies, preliminary in vivo data from two healthy controls and six patients with transfusional iron overload are presented. For both phantoms and human subjects, conventional R(2) and R(2)* relaxation rates are also measured in order to contrast the proposed method with established MRI iron quantification techniques. Quantification of dispersed (ferritin-like) iron may provide a new means of monitoring the risk of iron-induced toxicity in patients with iron overload and, together with quantification of aggregated (hemosiderin-like) iron, improve the accuracy of estimates for total storage iron. Magn Reson Med 63:1201-1209, 2010. (C) 2010 Wiley-Liss, Inc.