Etiologic factors of gastric cardiac adenocarcinoma among men in Taiwan
Etiologic factors of gastric cardiac adenocarcinoma among men in Taiwan
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DOI：
10.3748/wjg.15.5472
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发表时间：
2009-11-21
影响因子：
4.3
通讯作者：
Sung, Fung-Chang
中科院分区：
文献类型：
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作者：
Chen, Mei-Ju;Wu, Deng-Chyang;Sung, Fung-Chang
目的：探讨幽门螺杆菌(H Pylori)、生活方式、环境因素与男性贲门腺癌(GCA)的病因学关系。方法：2000-2009年在台湾进行了一项基于医院的病例对照研究。所有病例均为新确诊的原发GCA。与每个病例的年龄、性别和入院日期相匹配的五个对照组被选择。参与者在住院期间接受培训的面谈人员通过结构化问卷向参与者告知了潜在的危险因素，并提供了血液样本以确定幽门螺杆菌感染。用优势比(OR)和95%可信区间(95%CI)进行风险评估，并建立多因素条件Logistic回归模型。结果：本研究的受试者均为男性，包括41例病例和205例对照。单因素分析显示，幽门螺杆菌感染(OR=2.69，95%CI=1.30~5.53)、吸烟(OR=2.28，95%CI=1.05~4.96)、餐后工作或运动(OR=3.26，95%CI=1.31~8.11)、咸食(OR=2.51，95%CI=1.08~6.11)、新鲜蔬菜(OR=0.28，95%CI=0.09~0.80)、水果(OR=0.19，95%CI=0.04~0.89)和大米为主要食物(OR=0.53，95%CI=0.30~0.85)。多因素条件Logistic回归分析显示，工作或餐后锻炼(OR 3.18，95%CI 1.23~9.36)和幽门螺杆菌感染(OR 2.93，95%CI 1.42~6.01)与GCA的发病风险显著相关。而食用新鲜蔬菜(OR=0.22，95%CI=0.06~0.83)、水果(OR=0.28，95%CI=0.09~0.79)和大米(OR=0.48，95%CI=0.24~0.93)仍是GCA的重要危险因素。(C)2009年WJG Press和Baishiden。版权所有。
AIM: To elucidate etiologic associations between Helicobacter pylori (H pylori), lifestyle, environmental factors and gastric cardiac adenocarcinoma (GCA) among men.METHODS: A hospital-based case-control study was conducted in Taiwan from 2000 to 2009. All cases were newly confirmed as primary GCA. Five controls were selected matching with age, sex, and admission date to each case. Participants were informed of potential risk factors with a structured questionnaire by trained interviewers during hospitalization and provided a blood sample for the determination of H pylori infection. Odds ratio (OR) and 95% confidence interval (95% CI) were used to evaluate risk, and a multivariate conditional logistic regression model was performed.RESULTS: All participants recruited for this study were men, consisting of 41 cases and 205 controls. Results of the univariate analysis showed that significant factors associated with the etiology of GCA included H pylori (OR = 2.69, 95% CI = 1.30-5.53), cigarette smoking (OR = 2.28, 95% CI = 1.05-4.96), working or exercising after meals (OR = 3.26, 95% CI = 1.31-8.11), salted food (OR = 2.51, 95%CI = 1.08-6.11), fresh vegetables (OR = 0.28, 95% CI = 0.09-0.80), fruits (OR = 0.19, 95% CI = 0.04-0.89), and rice as principal food (OR = 0.53, 95% CI = 0.30-0.85). Multivariate conditional logistic regression models indicated that a significantly elevated risk of contracting GCA was associated with working or exercising after meals (OR 3.18, 95% CI 1.23-9.36) and H pylori infection (OR 2.93, 95% CI 1.42-6.01). In contrast, the consumption of fresh vegetables (OR = 0.22, 95% CI = 0.06-0.83), fruits (OR = 0.28, 95% CI = 0.09-0.79) and rice as principal food (OR = 0.48, 95% CI = 0.24-0.93) remained as significant beneficial factor associated with GCA.CONCLUSION: Working or exercising after meals and H pylori infection increase the risk of GCA, but higher intakes of rice, fresh vegetables and fruits reduce the risk. (C) 2009 The WJG Press and Baishideng. All rights reserved.