ALCOHOL-CONSUMPTION AND RISK OF CANCER IN HUMANS - AN OVERVIEW
ALCOHOL-CONSUMPTION AND RISK OF CANCER IN HUMANS - AN OVERVIEW
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DOI：
10.1016/0741-8329(94)00088-3
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发表时间：
1995-03-01
期刊：
影响因子：
2.3
通讯作者：
LONGNECKER, MP
中科院分区：
文献类型：
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作者：
LONGNECKER, MP
最近的流行病学数据继续支持酒精饮料消费是口腔癌、咽癌、喉癌、食道癌和肝癌的原因。特定酒精摄入量对这些癌症绝对风险的影响取决于其他风险因素的普遍性。酒精饮料消费是否是乳腺癌或大肠癌的原因尚不清楚。酒精摄入似乎不会增加患肺癌、膀胱癌、前列腺癌、胃癌、卵巢癌、子宫内膜癌或黑色素瘤的风险。间接的流行病学证据表明，酒精可能是胰腺癌的一个弱致病因素。还需要进一步的研究来确定适度饮酒的中年妇女如果减少酒精摄入量是否会稍微延长寿命。酒精可能导致癌症的生物学机制有很多。
Recent epidemiologic data continue to support alcoholic beverage consumption as a cause of cancer of the mouth, pharynx, larynx, esophagus, and liver. The effect of a given alcohol intake on absolute risk of these cancers depends on the prevalence of other risk factors. Whether alcoholic beverage consumption is a cause of cancer of the breast or large bowel is unclear. Alcohol intake appears not to increase risk of cancer of the lung, bladder, prostate, stomach, ovary, endometrium, or of melanoma. Indirect epidemiologic evidence suggests that alcohol may be a weak causal factor for pancreatic cancer. Additional research is needed to determine whether middle-aged women who drink moderately may experience a slight increase in longevity if they decrease alcohol intake. A number of biologically plausible mechanisms exist by which alcohol may cause cancer.