Energy metabolism as a regulator of ferroptosis
Energy metabolism as a regulator of ferroptosis
复制标题
能量代谢作为铁死亡的调节因子
DOI：
10.1080/15384101.2020.1838781
复制
发表时间：
2020-10-29
期刊：
影响因子：
4.3
通讯作者：
Lin, Weiqiang
中科院分区：
文献类型：
--
作者：
Ma, Yanhong;Han, Fei;Lin, Weiqiang
摘要铁凋亡是一种新发现的细胞死亡形式，它受到多种代谢途径的调节，包括铁、脂质和氨基酸。最近的两项研究表明，线粒体和能量应激也可以介导铁凋亡。Gao等人报道，线粒体在半胱氨酸剥夺诱导的铁凋亡中起重要作用。此外，Lee等人表明，能量应激部分通过激活AMP激活的蛋白激酶来抑制铁凋亡。这些发现为治疗铁中毒相关疾病，如癌症、组织损伤和神经退行性疾病提供了潜在的治疗策略。
ABSTRACT Ferroptosis is a newly identified form of cell death that is regulated by many metabolic pathways, including iron, lipid and amino acids. Recent two studies reveal that the mitochondria and energy stress could also mediate ferroptosis. Gao et al. report that mitochondria play an essential role in ferroptosis induced by cysteine deprivation. In addition, Lee et al. show that energy stress depressed ferroptosis partly through activation of AMP-activated protein kinase. These findings provide potential therapeutic strategies for treating ferroptosis-related diseases, such as cancer, tissue injury and neurodegenerative diseases.