Medial geniculate neurons show diverse effects in response to electrical stimulation of prefrontal cortex
Medial geniculate neurons show diverse effects in response to electrical stimulation of prefrontal cortex
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DOI：
10.1016/j.heares.2017.07.002
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发表时间：
2017-09-01
期刊：
影响因子：
2.8
通讯作者：
Mulders, W. H. A. M.
中科院分区：
文献类型：
--
作者：
Barry, K. M.;Robertson, D.;Mulders, W. H. A. M.
幽灵知觉被认为是由于丘脑水平的感觉门控功能障碍而产生的。最近，有人提出，耳鸣是一种对声音的幻觉，可能是由于皮质边缘回路的改变及其与听觉丘脑-内侧膝状核(MGN)的联系引起的。事实上，这种皮质-边缘回路的一些元素，如前额叶皮质(PFC)，以及听觉通路的元素，已经被证明在患有耳鸣的人类中发生了改变。然而，PFC和MGN之间的功能连接尚未被探索。因此，我们研究了激活PFC对正常麻醉Wistar大鼠MGN神经元活动的影响。双极电刺激PFC，同时记录MGN内单个神经元的活动。大多数(81%)MGN神经元的自发放电率在电刺激PFC时发生了变化。观察到的效应在神经元之间差异很大，包括具有广泛潜伏期的抑制和兴奋效应的组合。这些效应不依赖于声学反应类型或MGN细分。这些数据表明，激活PFC可以调节MGN神经元的活动，这种联系可能在听觉信号的感觉门控中发挥作用。(C)2017爱思唯尔B.V.保留所有权利。
Phantom perceptions have been proposed to arise due to dysfunctional sensory gating at the level of the thalamus. Recently, it has been suggested that tinnitus, a phantom perception of sound, may arise from altered cortico-limbic circuitry and its connection with the auditory thalamus, the medial geniculate nucleus (MGN). Indeed, some elements of this cortico-limbic circuitry, such as the prefrontal cortex (PFC), as well as elements of the auditory pathway, have been shown to be altered in humans with tinnitus. However, the functional connectivity between PFC and MGN has not yet been explored. We therefore investigated the effects of activation of the PFC on neuronal activity in MGN in normal anaesthetized Wistar rats. Bipolar electrical stimulation was delivered to the PFC while recording single neuron activity in the MGN. The majority (81%) of MGN neurons sampled showed a change in their spontaneous firing rate in response to electrical stimulation of the PFC. The effects observed varied greatly between neurons and included combinations of inhibitory and excitatory effects with a wide range of latencies. The effects were not dependent on acoustic response type or MGN subdivision. These data demonstrate that PFC activation can modulate MGN neuronal activity and this connection could potentially play a role in sensory gating of auditory signals. (C) 2017 Elsevier B.V. All rights reserved.