An Azo Coupling Strategy for Protein 3-Nitrotyrosine Derivatization

An Azo Coupling Strategy for Protein 3-Nitrotyrosine Derivatization
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蛋白质 3-硝基酪氨酸衍生化的偶氮偶联策略

DOI:
10.1002/chem.201901828
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发表时间:
2019-08-01
影响因子:
4.3
通讯作者:
Fang, Jianguo
Fang, Jianguo
中科院分区:
化学2区
文献类型:
--
作者:
Liu, Yuxin;Zhou, Pengcheng;Fang, Jianguo

文献摘要

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Herein, a strategy for the selective derivatization of 3-nitrotyrosine-containing proteins using the classic azo coupling reaction as the key step is described. This novel approach featured multiple advantages and was successfully applied to detect picomole levels of protein tyrosine nitration in biological samples.