Second generation video imaging technique for assessing dermal exposure (VITAE system)
Second generation video imaging technique for assessing dermal exposure (VITAE system)
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DOI：
10.1080/15428119791012423
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发表时间：
1997-09-01
期刊：
影响因子：
--
通讯作者：
Birnbaum, SG
中科院分区：
文献类型：
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作者：
Fenske, RA;Birnbaum, SG
第二代视频成像技术评估职业皮肤暴露（VITAE）的发展进行了描述，其性能进行了评价，并提出了新的程序暴露量化。与原型系统相比，目前的VITAE系统在像素阵列和灰度级方面具有更高的分辨率。在扩展现场部署期间评估了系统性能：在单个工人评估会话的数据采集期间，变异性为3-4%，在22天的研究期间，变异性为10%。受试者定位和图像勾画程序的变异性分别为2.7%和1.2%。使用皮肤上荧光示踪剂沉积的视觉观察将特定身体区域分类为暴露或未暴露，并针对视觉分类测试两个基于计算机的分类标准。这些标准通常更好地减少假阴性比假阳性分类，灵敏度和预测值分别达到95%和99%，当分析之前的一个子集的图像的presscribe。发现皮肤色素沉着的变化对荧光示踪剂定量具有实质性影响，从而导致新的校准程序的开发。通过在志愿受试者身上点样一系列示踪剂浓度并用VITAE系统定量荧光来生成标准曲线。然后，这些数据通过受试者或通过未暴露皮肤的背景信号的幅度进行分组。发现这两种分组方法控制皮肤色素沉着影响的能力相当，表明可以在不为每个受试者创建唯一曲线的情况下开发校准曲线。
Development of a second-generation video imaging technique for assessing occupational skin exposure (VITAE) is described, its performance evaluated, and new procedures for exposure quantification are presented. The current VITAE system has higher resolution in regard to both its picture element array and gray scale when compared with the prototype system. System performance was evaluated during extended field deployment: variability was 3-4% during data acquisition for individual worker evaluation sessions, and 10% over a 22-day study period. Variabilities attributable to subject positioning and image outlining procedures were 2.7 and 1.2%, respectively. Visual observations of fluorescent tracer deposition on skin were used to classify specific body regions as either exposed or unexposed, and two computer-based classification criteria were tested against the visual classifications. These criteria were generally better at minimizing false negative than false positive classification; sensitivity and predictive value reached 95 and 99%, respectively, when analysis was preceded by presampling of a subset of images. Variability in skin pigmentation was found to have a substantial effect on fluorescent tracer quantification, leading to development of new calibration procedures. Standard curves were generated by spotting a range of tracer concentrations on volunteer subjects and quantifying fluorescence with the VITAE system. These data were then grouped either by subject or by the magnitude of the background signal of the unexposed skin. The ability to control for the effects of skin pigmentation was found to be comparable for these two grouping methods, indicating that calibration curves can be developed without the creation of a unique curve for each subject.