Osteoporosis - Inflammatory Effects on Bone Metabolism and Fracture Risk
Osteoporosis - Inflammatory Effects on Bone Metabolism and Fracture Risk
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DOI：
10.1055/s-0034-1368247
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发表时间：
2014-04-01
影响因子：
1
通讯作者：
Lange, U.
中科院分区：
文献类型：
--
作者：
Dischereit, G.;Lange, U.
有大量证据表明，促炎细胞因子，特别是白介素1、白介素6和肿瘤坏死因子-α在骨代谢中发挥重要作用。此外，促炎细胞因子被怀疑在年龄和雌激素缺乏相关的骨丢失的发病机制中也很重要。尽管在慢性炎症性疾病患者中观察到骨量的加速下降，但促炎症细胞因子在骨质疏松病因中的确切意义仍不清楚。一些研究表明，促炎细胞因子浓度的增加与骨密度的下降以及骨折风险的增加之间存在关系。总而言之，证据相当稀少，不允许对单一细胞因子对骨骼代谢的影响做出任何明确的结论。为了更准确地确定全身炎症在骨质疏松症发病机制的哪个阶段起作用，还需要进一步的研究，特别是为临床医生开发合适的诊断标记物。这些诊断标记物可能能够识别有骨质疏松症风险的患者，从而预测骨折风险。因此，早期干预以保护骨骼健康，例如通过抗细胞因子治疗，可能会更有效和有效。
There is a large body of evidence that proinflammatory cytokines, particularly interleukin-1, interleukin-6, and tumour necrosis factor-alpha, play an important role in bone metabolism. Moreover, it is suspected that proinflammatory cytokines are also important in the pathogenesis of age- and estrogen deficiency-related bone loss. Although an accelerated decrease in bone mass is observed in patients with chronic inflammatory disorders, the definite meaning of proinflammatory cytokines in the aetiology of osteoporosis is still unclear. Some studies suggest a relationship between increased concentrations of proinflammatory cytokines and a decrease in bone mineral density, as well as an increased risk of fracture. In sum, the evidence is rather scarce and does not permit any clear conclusions about the effects of single cytokines in bone metabolism. To be able to define more exactly at which stage of the pathogenesis of osteoporosis parameters of a systemic inflammation take effect, further studies will be necessary, particularly for developing suitable diagnostic markers for clinicians. These diagnostic markers may be able to identify patients at risk for osteoporosis and therefore predict fracture risks. Thus, early interventions to preserve bone health, for example, by anti-cytokine therapy, could be more effective and efficient.