New insights into mechanism for the effect of resveratrol preconditioning against cerebral ischemic stroke: Possible role of matrix metalloprotease-9
New insights into mechanism for the effect of resveratrol preconditioning against cerebral ischemic stroke: Possible role of matrix metalloprotease-9
复制标题
白藜芦醇预处理抗缺血性脑卒中作用机制的新见解：基质金属蛋白酶9的可能作用
DOI：
10.1016/j.mehy.2007.04.033
复制
发表时间：
2008-01-01
影响因子：
4.7
通讯作者：
Li, Fanfan
中科院分区：
文献类型：
--
作者：
Dong, Wenpeng;Gao, Dakuan;Li, Fanfan
白藜芦醇是一种天然多酚类化合物，存在于一些可食用材料中，以其植物雌激素和抗氧化特性而闻名。越来越多的体内外证据表明白藜芦醇对缺血性脑卒中具有保护作用。本文就白藜芦醇对缺血性脑卒中的影响作一综述，并提出其可能的作用机制。在脑卒中后急性期，白藜芦醇预处理抑制基质金属蛋白酶-9的活性，以改善缺血和再灌注引起的血脑屏障破坏、水肿形成和神经细胞死亡。但在脑卒中后延迟期，白藜芦醇预处理通过增加基质金属蛋白酶-9的活性和表达，促进脑血管新生和脑再生。白藜芦醇对基质金属蛋白酶-9的影响在不同的阶段是有区别的，这是因为脑缺血后基质金属蛋白酶-9在神经血管单位细胞内的时间和空间重新分布。本文还假设，脑缺血后白藜芦醇治疗可能有利于脑血管生成和脑再生在中风后延迟阶段。(C)2007爱思唯尔有限公司版权所有。
Resveratrol, a natural polyphenotic compound, is found in a few edible materials and is well known for its phytoestrogenic and antioxidant properties. A growing body of in vivo and in vitro evidence indicates that resveratrol has protective effect on cerebral ischemic stroke. Here, we review the effect of resveratrol on cerebral ischemic stroke, and propose a possible mechanism. During acute phases after stroke, resveratrol preconditioning suppresses matrix metalloprotease-9 activity to ameliorate blood-brain barrier disruption, edema formation and neuronal cell death caused by ischemia and reperfusion. But during delayed phases after stroke, resveratrol preconditioning conduces to cerebral angiogenesis and brain regeneration through increasing matrix metalloprotease-9 activity and expression. Resveratrol's effect on matrix metalloprotease-9 is distinguishing in different phases because of temporal and spatial redistribution of matrix metalloprotease-9 within the cells of the neurovascular unit after cerebral ischemia. This paper also hypothesizes that resveratrol treatment after cerebral ischemia might be beneficial for cerebral angiogenesis and brain regeneration during delayed phases after stroke. (C) 2007 Elsevier Ltd. All rights reserved.