Comparison of corneal thickness after the instillation of topical anesthetics - Proparacaine versus oxybuprocaine
Comparison of corneal thickness after the instillation of topical anesthetics - Proparacaine versus oxybuprocaine
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DOI：
10.1097/01.ico.0000179929.97651.59
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发表时间：
2006-01-01
期刊：
影响因子：
2.8
通讯作者：
Seo, KY
中科院分区：
文献类型：
--
作者：
Nam, SM;Lee, HK;Seo, KY
目的：比较人角膜厚度的变化后，滴注丙美卡因与奥布卡因滴注后的时间超过10 minutes.Methods：18名健康的年轻参与者被招募。右眼使用丙美卡因，左眼使用奥布卡因。由1名观察者使用非接触式角膜反射显微镜每30秒测量一次左右基线角膜厚度，持续10分钟。基线角膜厚度定义为10分钟内所有数值的平均值。在右角膜上滴入1滴0.5%丙美卡因和在左角膜上滴入1滴0.4%奥布卡因后，每20秒测量一次角膜厚度的变化，持续10分钟。丙美卡因后角膜厚度增加8.6 μ m（类似于4.5-12.6 μ m，95%CI），然后在80秒内恢复到基线。应用奥布卡因后角膜厚度增加7.7 μ m（3.6-11.2 μ m，95% CI），然后在80秒内恢复至基线。有第二个短暂的增加约5分钟后，丙美卡因滴注后，但没有额外的短暂增加后，奥布卡因instillation.Conclusion：奥布卡因是类似的丙美卡因在其对角膜厚度的影响的严重程度。丙美卡因给药后5分钟内可能发生角膜厚度不稳定。在对青光眼患者进行屈光手术或中央角膜厚度测量时，应考虑局部麻醉剂滴注后角膜厚度的变化。
Purpose: To compare changes in human corneal thickness after the instillation of proparacaine with those after oxybuprocaine instillation with time over a period of 10 minutes.Methods: Eighteen healthy young participants were recruited. Proparacaine was used in the right eye and oxybuprocaine in the left. Right and left baseline corneal thicknesses were measured every 3 0 seconds for 10 minutes using a noncontact specular microscope by 1 observer. Baseline corneal thickness was defined as the average of all values taken over 10 minutes. Changes in corneal thickness were measured every 20 seconds for 10 minutes after the administration of 1 drop of 0.5% proparacaine onto the right cornea and 1 drop of 0.4% oxybuprocaine onto the left cornea.Results: Mean baseline right cornea thickness was 531 +/- 45 mu m, and that of the left cornea was 531 +/- 42 mu m. The corneal thickness after proparacaine increased by 8.6 mu m (similar to 4.5-12.6 mu m, 95% CI) and then returned to baseline within 80 seconds. Corneal thickness after applying oxybuprocaine increased by 7.7 mu m (3.6-11.2 mu m, 95% CI) and then returned to baseline within 80 seconds. There was a second transient increase about 5 minutes later after proparacaine instillation but no additional transient increase after oxybuprocaine instillation.Conclusion: Oxybuprocaine is similar to proparacaine in terms of the severity of its effect on corneal thickness. Corneal thickness instability may occur for 5 minutes after proparacaine administration. Changes in corneal thickness after topical anesthetic instillation should be considered when performing measurements for refractive surgery or central corneal thickness in glaucoma patients.