Is outpatient cognitive remediation therapy feasible to use in randomized clinical trials for anorexia nervosa?
Is outpatient cognitive remediation therapy feasible to use in randomized clinical trials for anorexia nervosa?
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门诊认知矫正疗法是否可以用于神经性厌食症的随机临床试验？
DOI：
10.1002/eat.22134
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Tchanturia,Kate
中科院分区：
文献类型：
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作者：
Lock,James;Agras,WStewart;Fitzpatrick,KathleenKara;Bryson,SusanW;Jo,Booil;Tchanturia,Kate
目的支持成人神经性厌食症（AN）特异性治疗的数据有限。成人AN的随机临床试验（rct）的特点是高损耗，限制了进行和解释现有研究的可行性。高辍学率可能与AN患者的不灵活和强迫性认知方式有关。本研究评估了在随机对照试验中使用认知修复疗法（CRT）来减少磨耗的可行性。方法46名参与者（平均年龄22.7岁，平均AN持续时间6.4年）随机接受8次为期2个月的CRT或认知行为治疗（CBT），随后16次为期4个月的CBT。结果在2个月的CRT与CBT治疗期间，CRT的损耗率（13%）低于CBT（33%）。2个月后，与CBT组相比，CRT组在认知效率低下方面有更大的改善。其他结果没有差异。这些结果表明，CRT在随机对照试验中用于AN的门诊治疗是可以接受和可行的。CRT可以在短期内减少人员流失。未来需要足够有力的研究来检验CRT作为an的门诊治疗。©2013 by Wiley journals, Inc. （Int J Eat Disord 2013; 46:56 67 - 575）
ObjectiveThere are limited data supporting specific treatments for adults with anorexia nervosa (AN). Randomized clinical trials (RCTs) for adults with AN are characterized by high attrition limiting the feasibility of conducting and interpreting existing studies. High dropout rates may be related to the inflexible and obsessional cognitive style of patients with AN. This study evaluated the feasibility of using cognitive remediation therapy (CRT) to reduce attrition in RCTs for AN.MethodForty‐six participants (mean age of 22.7 years and mean duration of AN of 6.4 years) were randomized to receive eight sessions of either CRT or cognitive behavioral therapy (CBT) over 2 months followed by 16 sessions of CBT for 4 months.ResultsDuring the 2‐month CRT vs. CBT treatment, rates of attrition were lower in CRT (13%) compared with that of CBT (33%). There were greater improvements in cognitive inefficiencies in the CRT compared with that of the CBT group at the end of 2 months. There were no differences in other outcomes.DiscussionThese results suggest that CRT is acceptable and feasible for use in RCTs for outpatient treatment of AN. CRT may reduce attrition in the short term. Adequately powered future studies are needed to examine CRT as an outpatient treatment for AN. © 2013 by Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:567–575)