Cord serum cotinine as a biomarker of fetal exposure to cigarette smoke at the end of pregnancy
Cord serum cotinine as a biomarker of fetal exposure to cigarette smoke at the end of pregnancy
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DOI：
10.2307/3434962
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发表时间：
2000-11-01
影响因子：
10.4
通讯作者：
Sunyer, J
中科院分区：
文献类型：
--
作者：
Pichini, S;Basagaña, X;Sunyer, J
本研究调查了妊娠末期胎儿暴露于香烟烟雾的生物标志物、脐带血清和母亲及新生儿尿液样本中的可替宁以及母亲自我报告问卷评估的吸烟量和暴露量的定量测量之间的关联。研究对象是来自西班牙巴塞罗那一家医院的429名母亲及其新生儿。在妊娠晚期和分娩当天完成一份包括吸烟习惯的问卷。脐带血中可替宁浓度与非吸烟者每日尼古丁暴露量和吸烟者每日尼古丁摄入量相关。脐带血清中可替宁浓度的几何平均值在统计学上区分了新生儿与非暴露和暴露的非吸烟母亲之间，以及这两个类别与吸烟者之间，并且还能够区分烟草烟雾暴露水平和三分位数分层的摄入水平。非吸烟母亲每天暴露于超过4 mg尼古丁的新生儿尿可替宁水平与其他两种暴露类别的水平存在统计学差异。新生儿和母亲尿液中的可替宁浓度在不吸烟母亲暴露于环境烟草烟雾（ETS）和不暴露于环境烟草烟雾（ETS）之间没有差异。脐带血清可替宁似乎是妊娠结束时胎儿暴露于吸烟的最适当的生物标志物，不仅区分主动吸烟与被动吸烟，而且区分暴露于ETS与非暴露。
This study investigated the association between biomarkers of fetal exposure to cigarette smoke at the end of pregnancy, cotinine in cord serum and in maternal and newborn urine samples, and quantitative measurement of smoking intake and exposure evaluated by maternal self-reported questionnaire. Study subjects were 429 mothers and their newborns from a hospital in Barcelona, Spain. A questionnaire including smoking habits was completed in the third trimester of pregnancy and on the day of delivery. Cotinine concentration in cord serum was associated with daily exposure to nicotine in nonsmokers and with daily nicotine intake in smokers. The geometric mean of cotinine concentration in cord serum statistically discriminated between newborns from nonexposed and exposed nonsmoking mothers, and between these two classes and smokers, and furthermore was able to differentiate levels of exposure to tobacco smoke and levels of intake stratified in tertiles. Urinary cotinine levels in newborns from nonsmoking mothers exposed to more than 4 mg nicotine daily were statistically different from levels in two other categories of exposure. Cotinine concentration in urine from newborns and from mothers did not differentiate between exposure and nonexposure to environmental tobacco smoke (ETS) in nonsmoking mothers. Cord serum cotinine appeared to be the most adequate biomarker of fetal exposure to smoking at the end of pregnancy, distinguishing not only active smoking from passive smoking, but also exposure to ETS from nonexposure.