Association of urinary phthalate metabolite concentrations with body mass index and waist circumference: a cross-sectional study of NHANES data, 1999-2002.
Association of urinary phthalate metabolite concentrations with body mass index and waist circumference: a cross-sectional study of NHANES data, 1999-2002.
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DOI：
10.1186/1476-069x-7-27
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发表时间：
2008-06-03
期刊：
影响因子：
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通讯作者：
Webster TF
中科院分区：
文献类型：
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作者：
Hatch EE;Nelson JW;Qureshi MM;Weinberg J;Moore LL;Singer M;Webster TF
虽然饮食和活动是肥胖症流行的关键因素，但实验室研究表明，内分泌干扰物也可能影响肥胖症。我们分析了6-80岁的国家健康和营养调查（NHANES）参与者尿液中测得的6种邻苯二甲酸酯代谢物与体重指数（BMI）和腰围（WC）之间的相关性。我们纳入了来自NHANES 1999-2002年的4369名参与者，其中有邻苯二甲酸单乙酯（MEP）、邻苯二甲酸单-2-乙基己酯（MEHP）、邻苯二甲酸单正丁酯（MBP）和邻苯二甲酸单苄酯（MBzP）的数据; 2286名参与者也有邻苯二甲酸单-2-乙基-5-羟己酯（MEHHP）和邻苯二甲酸单-2-乙基-5-氧代己酯（MEOHP）的数据（2001-2002年）。使用多元回归，我们计算平均BMI和WC邻苯二甲酸酯四分位数在8个年龄/性别特定的模型。在20-59岁的男性中，相关性最一致; BMI和WC在MBzP的四分位数中增加（校正的平均BMI = 26.7，27.2，28.4，29.0，p趋势= 0.0002），MEOHP，MEHHP，MEP和MBP也存在正相关性。在女性中，青春期女孩的BMI和WC随着MEP四分位数的增加而增加（校正的平均BMI = 22.9，23.8，24.1，24.7，p趋势= 0.03），在20-59奥尔兹中观察到类似但不太强烈的模式。相比之下，青春期女孩（校正平均BMI = 25.4、23.8、23.4、22.9，p趋势= 0.02）和20-59岁女性（校正平均BMI = 29.9、29.9、27.9、27.6，p趋势= 0.02）的MEHP与BMI呈负相关。在儿童中没有重要的关联，但在60-80奥尔兹中有几个反向关联。这项探索性横断面分析揭示了不同邻苯二甲酸酯代谢物与肥胖结局之间的许多有趣关联，包括性别和年龄亚组的显著差异。邻苯二甲酸酯等内分泌干扰物的影响可能取决于内源性激素水平，而内源性激素水平因年龄和性别而异。个别邻苯二甲酸盐也有不同的生物和激素效应。虽然我们的研究有局限性，但这两个因素都可以解释观察到的关联中的一些变化。这些初步数据支持在肥胖风险人群中进行前瞻性研究的必要性。
Although diet and activity are key factors in the obesity epidemic, laboratory studies suggest that endocrine disrupting chemicals may also affect obesity. We analyzed associations between six phthalate metabolites measured in urine and body mass index (BMI) and waist circumference (WC) in National Health and Nutrition Examination Survey (NHANES) participants aged 6–80. We included 4369 participants from NHANES 1999–2002, with data on mono-ethyl (MEP), mono-2-ethylhexyl (MEHP), mono-n-butyl (MBP), and mono-benzyl (MBzP) phthalate; 2286 also had data on mono-2-ethyl-5-hydroxyhexyl (MEHHP) and mono-2-ethyl-5-oxohexyl (MEOHP) phthalate (2001–2002). Using multiple regression, we computed mean BMI and WC within phthalate quartiles in eight age/gender specific models. The most consistent associations were in males aged 20–59; BMI and WC increased across quartiles of MBzP (adjusted mean BMI = 26.7, 27.2, 28.4, 29.0, p-trend = 0.0002), and positive associations were also found for MEOHP, MEHHP, MEP, and MBP. In females, BMI and WC increased with MEP quartile in adolescent girls (adjusted mean BMI = 22.9, 23.8, 24.1, 24.7, p-trend = 0.03), and a similar but less strong pattern was seen in 20–59 year olds. In contrast, MEHP was inversely related to BMI in adolescent girls (adjusted mean BMI = 25.4, 23.8, 23.4, 22.9, p-trend = 0.02) and females aged 20–59 (adjusted mean BMI = 29.9, 29.9, 27.9, 27.6, p-trend = 0.02). There were no important associations among children, but several inverse associations among 60–80 year olds. This exploratory, cross-sectional analysis revealed a number of interesting associations with different phthalate metabolites and obesity outcomes, including notable differences by gender and age subgroups. Effects of endocrine disruptors, such as phthalates, may depend upon endogenous hormone levels, which vary dramatically by age and gender. Individual phthalates also have different biologic and hormonal effects. Although our study has limitations, both of these factors could explain some of the variation in the observed associations. These preliminary data support the need for prospective studies in populations at risk for obesity.