Molecular Mechanisms of Nickel Allergy.
Molecular Mechanisms of Nickel Allergy.
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DOI：
10.3390/ijms17020202
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发表时间：
2016-02-02
影响因子：
5.6
通讯作者：
Ishimaru N
中科院分区：
文献类型：
--
作者：
Saito M;Arakaki R;Yamada A;Tsunematsu T;Kudo Y;Ishimaru N
对金属的过敏性接触超敏反应是一种迟发性过敏。虽然已知各种金属都能引起过敏反应，但镍是最常见的金属过敏原因。研究人员试图通过动物模型和人类患者来阐明金属过敏的机制。在此，基于先前的研究结果，包括最近发表的研究结果，描述了金属过敏的免疫学和分子机制。此外，还讨论了各种金属，特别是镍的吸附和排泄，以进一步了解金属过敏的发病机制。
Allergic contact hypersensitivity to metals is a delayed-type allergy. Although various metals are known to produce an allergic reaction, nickel is the most frequent cause of metal allergy. Researchers have attempted to elucidate the mechanisms of metal allergy using animal models and human patients. Here, the immunological and molecular mechanisms of metal allergy are described based on the findings of previous studies, including those that were recently published. In addition, the adsorption and excretion of various metals, in particular nickel, is discussed to further understand the pathogenesis of metal allergy.