50-kHz chirping (laughter?) in response to conditioned and unconditioned tickle-induced reward in rats:: effects of social housing and genetic variables
50-kHz chirping (laughter?) in response to conditioned and unconditioned tickle-induced reward in rats:: effects of social housing and genetic variables
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DOI：
10.1016/s0166-4328(00)00238-2
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发表时间：
2000-10-01
影响因子：
2.7
通讯作者：
Burgdorf, J
中科院分区：
文献类型：
--
作者：
Panksepp, J;Burgdorf, J
在这些研究中，实验人员测量了幼年大鼠有条件和无条件50kkz超声波发声(USVs)的发生率，以回应实验者奖励的手动挠痒。我们发现，隔离饲养的动物比社会饲养的动物发声更多，当它们的栖息地条件改变时，它们逐渐改变发声的倾向。与群居的SS相比，隔离的动物也表现出更快地获得挠痒的工具任务，并且表现出对挠痒的较少回避。隔离饲养的动物也表现出对50 khz紫外线的快速习得，而社交饲养的动物则不会。我们在四代内成功繁殖了对挠痒反应的高发音率和低发音率。与随机和低挠痒线相比，高挠痒线表现出更快的获得工具任务的速度，以及更少的回避df。他们也打得更多。最后，我们发现谷氨酸拮抗剂MK-801可以减少瘙痒诱导的50 kHzUSV，但对阿片类药物、多巴胺和胆碱能兴奋剂和阻滞剂有抵抗作用。总体而言，这些结果表明，挠痒诱发的50 khz USV可能是大鼠积极社会影响的有用行为标记物。对这些概念的困难也进行了讨论。(C)2000 Elsevier Science B.V.保留所有权利。
In these studies the incidence of conditioned and unconditioned 50-kKz ultrasonic vocalizations (USVs) in young rats was measured in response to rewarding manual tickling by an experimenter. We found that isolate-housed animals vocalize much more then socially housed ones, and when their housing conditions are reversed, they gradually shift their vocalization tendencies. Isolate-housed animals also show quicker acquisition of instrumental tasks for tickling, and exhibit less avoidance of tickling as compared to socially housed Ss. Isolate-housed animals also show rapid acquisition of 50-kHz USVs to a conditioned stimulus that predicts tickle reward, while socially housed animals do not. We successfully bred for high and low vocalization rates in response to tickling within four generations. The high tickle line showed quicker acquisition of an instrumental task for, as well as less avoidance df, tickling as compared to the random and low tickle lines. They also played more. Lastly, we found that the glutamate antagonist MK-801 can reduce tickle-induced 50-kHz USVs, but is resistant to opioid, dopamine and cholinergic stimulant and blocking agents. Overall, these results suggest that tickle evoked 50-kHz USVs may be a useful behavioral marker of positive social affect in rats. Difficulties with such concepts are also discussed. (C) 2000 Elsevier Science B.V. All rights reserved.