Mutational meltdown in asexual populations doomed to extinction
Mutational meltdown in asexual populations doomed to extinction
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DOI：
10.1007/s00285-023-02019-y
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发表时间：
2023-10-01
影响因子：
1.9
通讯作者：
Azevedo，Ricardo B. R.
中科院分区：
文献类型：
--
作者：
Olofsson，Peter;Chipkin，Logan;Azevedo，Ricardo B. R.
无性繁殖的种群会通过一个被称为穆勒棘轮的过程积累有害的突变。林奇和他的同事们提出，棘轮最终导致突变积累和种群下降的恶性循环，从而导致种群灭绝。他们称这种现象为突变熔毁。在这里，我们使用多类型的分支过程模型分析突变崩溃，在突变的存在下，种群注定要灭绝。在此模型下，我们分析了种群规模和组成的变化以及灭绝时间。
Asexual populations are expected to accumulate deleterious mutations through a process known as Muller’s ratchet. Lynch and colleagues proposed that the ratchet eventually results in a vicious cycle of mutation accumulation and population decline that drives populations to extinction. They called this phenomenon mutational meltdown. Here, we analyze mutational meltdown using a multi-type branching process model where, in the presence of mutation, populations are doomed to extinction. We analyse the change in size and composition of the population and the time of extinction under this model.