Serum Vitamins and Heavy Metals in Blood and Urine, and the Correlations among Them in Parkinson's Disease Patients in China
Serum Vitamins and Heavy Metals in Blood and Urine, and the Correlations among Them in Parkinson's Disease Patients in China
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DOI：
10.1159/000328253
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发表时间：
2011-01-01
影响因子：
5.7
通讯作者：
Kanda, Hideyuki
中科院分区：
文献类型：
--
作者：
Fukushima, Tetsuhito;Tan, Xiaodong;Kanda, Hideyuki
背景资料：一些重金属被怀疑是致病的，一些维生素对帕金森病（PD）的保护，和重金属和维生素之间的相互作用可能与PD的病理生理。方法：受试者包括PD患者和从中国门诊招募的性别和年龄匹配的对照。早晨的血液和尿液样本被用来测量金属和维生素的浓度。结果：PD患者血清铁、全血锰、尿铁、尿铜水平均显著高于对照组。PD患者血铁与尿铁浓度相关性显著。PD患者血清维生素E/尿铜比值显著低于对照组。PD患者血清维生素E与血铜呈负相关，与尿铜呈正相关。血清维生素B（12）与血清锌呈正相关，与尿锌呈负相关。结论：铁、铜摄入过多、锰蓄积、维生素E/铜摄入失衡、锌缺乏导致维生素B 12减少可能是PD的病因之一。版权所有（C）2011 S. Karger AG，巴塞尔
Background: Some heavy metals are suspected to be pathogenic and some vitamins protective against Parkinson's disease (PD), and the interaction between heavy metals and vitamins could be associated with the pathophysiology of PD. Methods: Subjects comprised PD patients and sex-and age-matched controls recruited from an outpatient clinic in China. Morning blood and urine samples were used to measure concentrations of metals and vitamins. Results: The serum iron, whole-blood manganese, urine iron and copper levels were significantly higher in the PD patients than in the controls. The correlation coefficient between serum and urine concentrations of iron in the PD patients was significant. The serum vitamin E/urine copper ratio was significantly lower in the PD patients than in the controls. Serum vitamin E was negatively correlated with serum copper and was positively correlated with urine copper in the PD patients. Serum vitamin B(12) was positively correlated with serum zinc in the PD patients and was negatively correlated with urine zinc in the controls. Conclusions: Excessive intake of iron and copper, accumulation of manganese, vitamin E/copper imbalance in intake, and vitamin B 12 decrease by zinc deficiency in the body might be involved in the etiology of PD. Copyright (C) 2011 S. Karger AG, Basel