Porous bioceramic bead prepared by calcium phosphate with sodium alginate gel and PE powder
Porous bioceramic bead prepared by calcium phosphate with sodium alginate gel and PE powder
复制标题
磷酸钙、海藻酸钠凝胶和PE粉末制备多孔生物陶瓷珠
DOI：
10.1016/j.msec.2007.09.001
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Chih
中科院分区：
文献类型：
--
作者：
Y. Fu;M. Ho;Shun;H. Hsieh;Chih
The porous calcium phosphate beads were made by an alginate-interacting Ca ions mechanism on addition of a pore-forming polyethylene (PE) powder at 1250 °C sintering. The nature of the powders and porous beads were analyzed through X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR) and heavy metal analysis by inductively coupled plasma-optical emission spectroscopy (ICP-OES). The porous beads size and the pore microstructure characteristics were determined using scanning electron microscopy (SEM). Beside, the porosity analysis was evaluated out using an Archimedes' principle and mercury porosimetry. Then, the sodium ampicillin was penetrated/adsorbed onto calcium-deficient hydroxyapatite porous beads, and was subsequently released in PBS. No matter whether the raw material was HAp, TCP or biphase, the Ca9(HPO4)(PO4)5OH phase (CDHA) was formed only after sintering. Porous beads of various calcium phosphates with different sizes (0.9–1.1 mm) and pore size groups (60–120 μm and lower than 10 μm) were appeared. The release kinetics of sodium ampicillin from these porous beads have indicated the possibility of using these materials as possible carriers for drug delivery.
