Palmar-plantar erythrodysesthesia secondary to docetaxel chemotherapy: a case report.
Palmar-plantar erythrodysesthesia secondary to docetaxel chemotherapy: a case report.
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DOI：
10.1186/1752-1947-5-80
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发表时间：
2011-02-25
影响因子：
1
通讯作者：
Al-Niaimi A
中科院分区：
文献类型：
--
作者：
Benghiat H;Al-Niaimi A
多西紫杉醇是一种化疗药物，可单独或联合使用，用于治疗许多肿瘤性疾病。因此，许多副作用得到了很好的描述。掌跖红肿感觉虽然是某些类型化疗相对常见的副作用，但多西紫杉醇很少发生，并且通常归因于其他药物。我们报告了一名 66 岁白人女性的病例，她因浸润性乳腺癌接受了多西紫杉醇单药辅助治疗。在第一个治疗周期后，她出现了掌跖红肿感觉异常，因此需要改变治疗方法。掌跖红肿感觉是细胞毒性化疗的一种相对常见的副作用，特别是使用 5-氟尿嘧啶、卡培他滨和脂质体阿霉素等药物时。多西紫杉醇通常单独使用或与许多这些药物联合使用来治疗各种恶性病症。我们想强调多西紫杉醇单药治疗导致掌跖红肿感觉的发生，因此可以将其视为接受与已知可引起这种毒性的化疗药物联合治疗的患者的潜在原因。
Docetaxel is a chemotherapeutic agent used alone or in combination for the management of many neoplastic conditions. Numerous side effects are well described as a consequence. Palmar-plantar erythrodysesthesia, although a relatively common side effect of some types of chemotherapy, occurs infrequently with docetaxel and is often attributed to other drug agents. We report the case of a 66-year-old Caucasian woman who received adjuvant docetaxel monotherapy for invasive breast cancer. She developed palmar-plantar erythrodysesthesia following her first cycle of treatment, which necessitated a change in management. Palmar-plantar erythrodysesthesia is a relatively common side effect of cytotoxic chemotherapy, particularly with drugs such as 5-fluorouracil, capecitabine and liposomal doxorubicin. Docetaxel is commonly used both alone and in combination with a number of these agents for the management of various malignant conditions. We would like to highlight the occurrence of palmar-plantar erythrodysesthesia as a result of docetaxel monotherapy so that it can be considered as a potential cause in patients receiving combination treatment with chemotherapeutic agents better known to cause this toxicity.