Quadriceps strength is a sensitive marker of disease progression in sporadic inclusion body myositis
Quadriceps strength is a sensitive marker of disease progression in sporadic inclusion body myositis
复制标题
DOI：
10.1016/j.nmd.2012.05.004
复制
发表时间：
2012-11-01
影响因子：
2.8
通讯作者：
Hogrel, Jean-Yves
中科院分区：
文献类型：
--
作者：
Allenbach, Yves;Benveniste, Olivier;Hogrel, Jean-Yves
目前没有有效的治疗方法来恢复散发性包涵体肌炎的肌肉功能。这种疾病的自然史研究很少。本研究的目的是确定散发性包涵体肌炎患者的功能模式，并在9个月内跟踪其变化，以确定未来临床试验最敏感的结局指标。22例确诊为散发性包涵体肌炎的患者采用临床和功能量表进行评估。采用测力法评价握力和腕、肘、踝、膝关节屈伸力量。其中16例患者在9个月后重新评估。平均整体综合指数为预测正常值的43.3 +/- 16.5%。最弱的肌肉功能是上肢的握力、屈腕和屈肘，下肢的伸膝和屈踝。肌无力通常是不对称的，尤其是上肢，所有测试功能在优势侧明显更强。患者力量仅与膝关节伸展的疾病持续时间相关，这也是9个月内唯一显著变化的肌肉功能。膝关节伸展强度似乎是散发性包涵体肌炎疾病进展的最相关标志物，当用适当的测力法测量时。(C)2012 Elsevier B. V.保留所有权利。
There are currently no effective treatments to restore the muscle function in sporadic inclusion body myositis. Natural history studies of this disease are scarce. The goal of this study consisted in defining the functional pattern of patients with sporadic inclusion body myositis and to follow its change over a 9-month period to determine the most sensitive outcome measures for future clinical trials. Twenty-two patients with definite sporadic inclusion body myositis were assessed using clinical and functional scales. Dynamometry was used to evaluate the strength for hand grip and wrist, elbow, ankle and knee flexion and extension. Among the patients, 16 were reassessed 9 months later. The mean whole composite index was at 43.3 +/- 16.5% of the predicted normal values. The weakest muscle functions were hand grip, wrist flexion and elbow flexion at the upper limbs and knee extension and ankle flexion at the lower limbs. Muscle weakness was generally asymmetrical, especially for upper limbs where all tested functions were significantly stronger at the dominant side. The patient strength was correlated with the disease duration only for knee extension, which was also the only muscle function to change significantly over 9 months. Knee extension strength seems to be the most relevant marker of disease progression in sporadic inclusion body myositis when measured with suitable dynamometry. (C) 2012 Elsevier B.V. All rights reserved.