Angiotensin II Type 1 Receptor Expression and Microvessel Density in Human Bladder Cancer
Angiotensin II Type 1 Receptor Expression and Microvessel Density in Human Bladder Cancer
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DOI：
10.1016/j.urology.2010.11.002
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发表时间：
2011-04-01
期刊：
影响因子：
2.1
通讯作者：
Oya, Mototsugu
中科院分区：
文献类型：
--
作者：
Shirotake, Suguru;Miyajima, Akira;Oya, Mototsugu
OBJECTIVES To determine whether angiotensin II type 1 receptor (AT1R) expression and tumor angiogenesis in human bladder cancer (BCa) specimens acquired by transurethral resection (TUR). It has recently been reported that AT1R is expressed in several tumors and is involved in tumor angiogenesis. However, no study has investigated AT1R expression in association with angiogenesis in clinical specimens of bladder cancer.METHODS Surgical specimens were obtained from 108 patients who had undergone TUR for bladder cancer. All specimens were pathologically diagnosed as urothelial carcinoma. AT1R expression and microvessel density (MVD) were determined by immunostaining. The clinical and pathologic characteristics were retrospectively reviewed.RESULTS The MVD was greater in muscle-invasive BCa (MIBC; 29 cases, 34.4 +/- 4.1/0.25 mm(2)) than in non-MIBC (NMIBC; 79 cases, 17.4 +/- 1.1/0.25 mm(2), P
