Reconsolidation-Extinction Interactions in Fear Memory Attenuation: The Role of Inter-Trial Interval Variability.
Reconsolidation-Extinction Interactions in Fear Memory Attenuation: The Role of Inter-Trial Interval Variability.
复制标题
恐惧记忆衰减中的重新溶解 - 伸展相互作用：试验间隔变异性的作用。
DOI：
10.3389/fnbeh.2017.00002
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发表时间：
2017
影响因子：
3
通讯作者：
Monfils MH
中科院分区：
文献类型：
--
作者：
Auchter A;Cormack LK;Niv Y;Gonzalez-Lima F;Monfils MH
恐惧的消失通常会导致新的抑制性记忆的形成，这种记忆会抑制原有的条件反应。证据还表明，在检索诱发的不稳定期进行的消退训练导致消退记忆与原始恐惧记忆的整合，使恐惧记忆不易恢复。本研究考察了检索-消失范式在记忆更新中最有效的参数。具体来说，我们操纵了条件刺激（CS）在消退过程中的试验间隔（ITIs），研究了不同程度变化的间隔长度如何影响记忆更新的强度。我们发现，在消失过程中，随机化CS表现的ITI比固定ITI的消失导致更少的恐惧恢复。在记忆消失过程中接受可变记忆刺激的受试者在记忆消失过程中也表现出更高的冻结性，表明记忆消失过程中随机化的记忆刺激导致了更高的总体反应性，这可能是记忆更新的一种潜在机制。
Fear extinction typically results in the formation of a new inhibitory memory that suppresses the original conditioned response. Evidence also suggests that extinction training during a retrieval-induced labile period results in integration of the extinction memory into the original fear memory, rendering the fear memory less susceptible to reinstatement. Here we investigated the parameters by which the retrieval-extinction paradigm was most effective in memory updating. Specifically, we manipulated the inter-trial intervals (ITIs) between conditional stimulus (CS) presentations during extinction, examining how having interval lengths with different degrees of variability affected the strength of memory updating. We showed that randomizing the ITI of CS presentations during extinction led to less return of fear via reinstatement than extinction with a fixed ITI. Subjects who received variable ITIs during extinction also showed higher freezing during the ITI, indicating that the randomization of CS presentations led to a higher general reactivity during extinction, which may be one potential mechanism for memory updating.