Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort
Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort
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DOI：
10.1183/13993003.00779-2015
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发表时间：
2015-11-01
影响因子：
24.3
通讯作者：
Chung, Kian Fan
中科院分区：
文献类型：
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作者：
Shaw, Dominick E.;Sousa, Ana R.;Chung, Kian Fan
U-BIOPRED是一个由20个学术机构、11家制药公司和6个患者组织组成的欧盟联盟，其目标是使用系统生物学方法提高对哮喘疾病机制的理解。这项对来自11个欧洲国家的重度哮喘、轻度/中度哮喘和健康对照的成人的横断面评估包括对患者报告的结果、肺功能、严重哮喘患者（不吸烟者，n=311;吸烟者/既往吸烟者，n=110）与轻度/中度疾病患者（n=88）相比，有更多的症状和加重（2.5次加重对前12个月的0.4次加重; p
U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective of improving the understanding of asthma disease mechanisms using a systems biology approach.This cross-sectional assessment of adults with severe asthma, mild/moderate asthma and healthy controls from 11 European countries consisted of analyses of patient-reported outcomes, lung function, blood and airway inflammatory measurements.Patients with severe asthma (nonsmokers, n=311; smokers/ex-smokers, n=110) had more symptoms and exacerbations compared to patients with mild/moderate disease (n=88) (2.5 exacerbations versus 0.4 in the preceding 12 months; p