Functional improvement precedes structural regression of atherosclerosis.
Functional improvement precedes structural regression of atherosclerosis.
复制标题
功能改善先于动脉粥样硬化的结构消退。
DOI：
10.1161/01.cir.89.4.1810
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发表时间：
1994
期刊：
影响因子：
37.8
通讯作者：
Heistad,DD
中科院分区：
文献类型：
--
作者：
Benzuly,KH;Padgett,RC;Kaul,S;Piegors,DJ;Armstrong,ML;Heistad,DD
基础：在饮食诱导的动脉粥样硬化猴子中，对5-羟色胺的血管收缩反应增强，并且在正常饮食18个月后改善。我们测试了这一假设，即功能的改善可能发生在早期的回归过程中，在证据的结构improvement.METHODS和provisions髂动脉血清素的反应进行了测量，通过定量血管造影术和多普勒血流探头在几组猴子：（1）正常猴子，（2）喂食致动脉粥样硬化饮食2年的猴子（动脉粥样硬化），和（3）猴子喂养致动脉粥样硬化饮食2年（消退前），然后正常饮食4、8或12个月（消退）。在正常的猴子中，血清素对髂动脉的收缩作用很小，流向腿部的血流量增加。在动脉粥样硬化的猴子中，髂动脉明显收缩，流向腿部的血流量明显减少。经过4个月的回归饮食，八只猴子中的四只表现出显着降低血管造影对血清素的高反应性，并在8个月，八只猴子中的六个有显着改善。回归后，5-羟色胺对血流的影响最小。有没有减少内膜面积（即，动脉粥样硬化病变）在髂动脉的回归猴相比，动脉粥样硬化猴，但有一个显着减少胆固醇酯在动脉中的回归monkeys.CONCLUSIONSAbnormal血管收缩反应血清素通常返回或向正常的几个月内回归动脉粥样硬化。功能改善与动脉壁脂质的早期再吸收同时发生，并且发生在动脉粥样硬化病变质量的可检测变化之前。
BACKGROUNDVasoconstrictor responses to serotonin are augmented in monkeys with diet-induced atherosclerosis and improve after 18 months of normal diet. We tested the hypothesis that functional improvement may occur early during regression, before evidence of structural improvement.METHODS AND RESULTSResponses of the iliac artery to serotonin were measured by quantitative angiography and a Doppler flow probe in several groups of monkeys: (1) normal monkeys, (2) monkeys fed an atherogenic diet for 2 years (atherosclerotic), and (3) monkeys fed an atherogenic diet for 2 years (preregression) followed by a normal diet for 4, 8, or 12 months (regression). In normal monkeys, serotonin produced minimal constriction of the iliac artery, and blood flow to the legs increased. In atherosclerotic monkeys, there was pronounced constriction of the iliac artery, and blood flow to the legs decreased markedly. After 4 months of regression diet, four of eight monkeys demonstrated marked reduction in hyperresponsiveness to serotonin angiographically, and by 8 months, six of eight monkeys had significant improvement. After regression, serotonin produced minimal changes in flow. There was no reduction in intimal area (ie, atherosclerotic lesion) in iliac arteries from regression monkeys compared with atherosclerotic monkeys, but there was a marked reduction in cholesteryl ester in arteries from regression monkeys.CONCLUSIONSAbnormal vasoconstrictor responses to serotonin usually return to or toward normal within a few months during regression of atherosclerosis. Functional improvement occurs in conjunction with early resorption of lipid from the arterial wall and occurs before detectable changes in mass of the atherosclerotic lesion.