In Vitro Activities of a New Lipopeptide, HMR 1043, against Susceptible and Resistant Gram-Positive Isolates
In Vitro Activities of a New Lipopeptide, HMR 1043, against Susceptible and Resistant Gram-Positive Isolates
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新型脂肽 HMR 1043 针对敏感和耐药革兰氏阳性菌株的体外活性
DOI：
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发表时间：
2003
影响因子：
4.9
通讯作者：
H. Drugeon
中科院分区：
文献类型：
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作者：
P. Bémer;M. Juvin;A. Bryskier;H. Drugeon
摘要本研究的目的是比较HMR 1043与达托霉素和替考拉宁对革兰氏阳性分离株的活性。对52株菌株、26株亲本菌株（包括葡萄球菌、链球菌、肠球菌和葡萄球菌菌株）和26株HMR 1043耐药突变株（通过使用Szybalski方法从亲本菌株获得）进行了药敏试验。按照NCCLS概述的程序进行琼脂稀释和纸片扩散敏感性试验。HMR 1043对敏感和耐药革兰氏阳性菌表现出良好的活性。HMR 1043的体外活性受钙离子存在的影响小于达托霉素。未定义药敏试验折点，因为用不同检测纸片获得的相关系数较差。
ABSTRACT The purpose of this study was to compare the activity of HMR 1043 with those of daptomycin and teicoplanin against gram-positive isolates. Susceptibility tests were performed for 52 strains, 26 parental strains, including staphylococcal, streptococcal, enterococcal, and listerial strains, and 26 HMR 1043-resistant mutants obtained from parental strains by using the Szybalski method. Agar dilution and disk diffusion susceptibility tests were performed by the procedures outlined by the NCCLS. HMR 1043 demonstrated good activity against susceptible and resistant gram-positive bacteria. The activity of HMR 1043 in vitro was less influenced by the presence of calcium ions than that of daptomycin. Susceptibility test breakpoints were not defined because of the poor correlation coefficients obtained with the different disks tested.