Management of the Premenstrual Syndrome by Subcutaneous Implants of Oestradiol
Management of the Premenstrual Syndrome by Subcutaneous Implants of Oestradiol
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皮下植入雌二醇治疗经前综合症
DOI：
10.3109/01674828409017452
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发表时间：
1984
影响因子：
3.1
通讯作者：
J. Studd
中科院分区：
文献类型：
--
作者：
A. Magos;W. Collins;J. Studd
通过皮下植入雌二醇抑制卵巢周期性活动已被用于治疗92例经前综合征（PMS）患者，其中16例同时患有经期偏头痛。该治疗通常初始剂量为100毫克雌二醇，每6个月减少到50毫克，持续治疗长达7年，平均治疗时间为2.0年；80%的患者植入了不止一次，32%的患者植入了5次或更多。84%的患者报告经前症候群症状完全或几乎完全缓解。先前的药物减少或停药83%。在与以前的治疗方法进行比较的84%中，93%的人认为种植治疗是最有效的。周期给予孕激素，一般为每月7-10天，以诱导有规律的停药性出血，防止子宫内膜增生。这与45%的患者的特征性经前症状的恢复有关，但程度较轻，持续时间较短。
The suppression of cyclical ovarian activity by subcutaneous implants of oestradiol has been used to treat the premenstrual syndrome (PMS) in 92 patients, including 16 who also suffered from menstrual migraine. The treatment, usually with an initial dose of 100 mg oestradiol, reduced to 50 mg every 6 months, has continued for upto 7 years, with a mean duration of therapy of 2.0 years; 80% of patients have had more than one implant, and 32% have had five or more. Complete or almost complete relief of the symptoms of the PMS was reported by 84%. Previous medication was reduced or discontinued by 83%. Of the 84% where a comparison could be made with previous treatments, 93% considered implant therapy to be the most effective.Progestogen was given cyclically, usually for 7-10 days each month, to induce regular withdrawal bleeding and prevent endometrial hyperplasia. This was associated with the return of the patients' characteristic premenstrual symptoms in 45%, but to a lesser degree and for a shorter durati...