Eph receptor tyrosine kinases in angiogenesis: From development to disease
Eph receptor tyrosine kinases in angiogenesis: From development to disease
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DOI：
10.1023/b:agen.0000037340.33788.87
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发表时间：
2004-01-01
期刊：
影响因子：
9.8
通讯作者：
Chen, Jin
中科院分区：
文献类型：
--
作者：
Brantley-Sieders, Dana M.;Chen, Jin
血管生成，即新血管从现有血管系统中发芽和分支的过程，对于胚胎发生期间和正常组织稳态（如女性生殖道）中的血管重塑至关重要。血管生成还可以有助于疾病如癌症和视网膜病的发病机制。Eph家族的受体酪氨酸激酶及其配体，称为ephrin，已成为胚胎血管重塑的关键调节因子。最近，这些分子与出生后血管生成重塑和肿瘤新血管形成有关。本文综述了Eph/ephrins在血管生成中的最新进展，重点是发展和疾病，以及在抗血管生成治疗中靶向这些分子的潜力。
Angiogenesis, the process by which new blood vessels sprout and branch from existing vasculature, is crucial for vascular remodeling during embryogenesis and in normal tissue homeostasis, such as in the female reproductive tract. Angiogenesis can also contribute to the pathogenesis of diseases such as cancer and retinopathy. The Eph family of receptor tyrosine kinases and their ligands, called ephrins, has emerged as critical regulators of vascular remodeling in the embryo. More recently, these molecules have been associated with post-natal angiogenic remodeling and tumor neovascularization. This review provides an overview of recent advances in our understanding of Eph/ephrins in angiogenesis, with an emphasis on development and disease, and the potential for targeting these molecules in anti-angiogenic therapy.