Tissue instruction for migration and retention of TRM cells.
Tissue instruction for migration and retention of TRM cells.
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DOI：
10.1016/j.it.2015.07.002
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发表时间：
2015-09
影响因子：
16.8
通讯作者：
Iwasaki A
中科院分区：
文献类型：
--
作者：
Iijima N;Iwasaki A
在感染过程中，效应T细胞的一个亚群播撒在淋巴组织和非淋巴组织中，并产生组织驻留记忆T细胞(TRM)。最近的发现为深入了解TRM细胞归巢的组织指导的分子和细胞机制，以及涉及它们的保留和维持的程序提供了洞察。我们在这里回顾了这些发现，强调了CD4TRM和CD8TRM细胞的共同特征和区别。在此背景下，我们研究了记忆淋巴细胞团(MLC)的作用，并提出MLC作为一个即时反应中心，由处于待命状态的TRM细胞组成，能够检测传入的病原体并建立强大的局部免疫反应，以遏制和限制感染源的传播。
During infection, a subset of effector T cells seeds the lymphoid and non-lymphoid tissues and gives rise to tissue-resident memory T cells (TRM). Recent findings have provided insight into the molecular and cellular mechanisms underlying tissue instruction of TRM cell homing, as well as the programs involved in their retention and maintenance. We review these findings here, highlighting both common features and distinctions between CD4 TRM and CD8 TRM cells. In this context we examine the role of memory lymphocyte clusters (MLCs), and propose that the MLCs serve as an immediate response center consisting of TRM cells on standby, capable of detecting incoming pathogens and mounting robust local immune responses to contain and limit the spread of infectious agents.