Methods to sustain drug efficacy in helminth control programmes
Methods to sustain drug efficacy in helminth control programmes
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DOI：
10.1016/s0001-706x(03)00043-3
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发表时间：
2003-05-01
期刊：
影响因子：
2.7
通讯作者：
Albonico, M
中科院分区：
文献类型：
--
作者：
Albonico, M
评估驱虫治疗在公共卫生方面的效果是一个广泛的概念，它超越了寄生虫学方法，应根据几种发病率指标明确界定。有几个因素可能影响驱虫药物的疗效。药物的质量是一个非常重要的问题，特别是在当地作为非专利产品生产并用于大规模基于化疗的控制规划时。其他因素包括药物-患者相互作用、宿主-寄生虫关系、使用的诊断方法、寄生虫菌株之间的遗传变异和诱导的耐药性。兽医科学家警告说，可以通过频繁地对绵羊和山羊进行大规模治疗来选择耐药性，并且已经发展了一套关于评估对兽医具有重要意义的线虫的疗效和检测耐药性的知识体系。在人类土壤传播线虫感染中，卵减少率（ERR）、卵孵化测定（EHA）和新的分子生物学技术可用于监测寄生虫控制规划中的药物疗效和发现耐药性的早期发生。最近的研究和预防或延缓人类土壤传播的线虫出现耐药性的战略提出了一些驱虫类药物效力降低的证据。(C) 2003 Elsevier Science B.V.版权所有
Assessment of the efficacy of anthelminthic treatment in public health is a broad concept, which goes beyond parasitological methods and should be clearly defined according to several indicators of morbidity. Several factors may influence the efficacy of anthelminthic drugs. The quality of drug is an issue of great importance, especially when produced locally as a generic product and used in large-scale chemotherapy-based control programmes. Other factors include the drug-patient interaction, the host-parasite relationship, the diagnostic method used, genetic variations between parasite strains and induced drug resistance. Veterinary scientists have warned that drug resistance can be selected through frequent mass treatment of sheep and goats and have developed a body of knowledge on evaluation of efficacy and detection of resistance in nematodes of veterinary importance. In soil-transmitted nematodes infections of humans, the egg reduction rate (ERR), the egg hatch assay (EHA) and novel molecular biological techniques may be used to monitor drug efficacy in helminth control programmes and to detect early occurrence of resistance. Evidence of reduced drug efficacy of some anthelminthics has been suggested by recent studies and strategies to prevent or delay the emergence of drug resistance in human soil-transmitted nematodes. (C) 2003 Elsevier Science B.V. All rights reserved.