Unusual repertoire of vocalizations in the BTBR T+tf/J mouse model of autism.
Unusual repertoire of vocalizations in the BTBR T+tf/J mouse model of autism.
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DOI：
10.1371/journal.pone.0003067
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发表时间：
2008-08-27
期刊：
影响因子：
3.7
通讯作者：
Crawley, Jacqueline N.
中科院分区：
文献类型：
--
作者：
Scattoni, Maria Luisa;Gandhy, Shruti U.;Ricceri, Laura;Crawley, Jacqueline N.
BTBR T+ tf/J（BTBR）是一种近交系小鼠品系，其表现出类似于自闭症的第一和第三诊断症状的社交异常和重复行为。在这里，我们调查BTBR的超声发声，以解决自闭症的第二个诊断症状，沟通障碍。与常用的C57 BL/6 J（B6）品系相比，BTBR幼崽在与母亲和兄弟姐妹分离时会发出更大的声音，更频繁地呼叫。对10类呼叫的详细分析显示，与B6相比，BTBR中存在一种不寻常的模式。BTBR发出高水平的谐波，双音节，和复合呼叫，但最小数量的人字形音节，向上，向下，和短的呼叫。由于BTBR幼仔的体重高于B6幼仔，一种可能的解释是较大的胸部尺寸导致了更响亮的叫声和音节类别的不同分布。为了测试这种可能性，我们记录了FVB/NJ（体重与BTBR相似的品系）和129 X1/SvJ（体重与B6相似的品系）的分离结果。BTBR仍然是呼叫数量的异常值，显示复杂、向上、V形、短和频率阶跃呼叫的数量较低，沿着高谐波和复合。此外，BTBR的发育里程碑和生长速度加快，表明不寻常的神经发育轨迹。总的来说，我们的研究结果表明，在遗传上不同的小鼠品系中，超声波呼叫的特定模式可能代表不同的词汇，或复杂声乐曲目的先天变化。特别有趣的是不寻常的发声模式和更频繁，响亮的谐波在BTBR自闭症小鼠模型中很明显，这可能类似于在一些自闭症婴儿中看到的非典型发声。
BTBR T+ tf/J (BTBR) is an inbred mouse strain that displays social abnormalities and repetitive behaviors analogous to the first and third diagnostic symptoms of autism. Here we investigate ultrasonic vocalizations in BTBR, to address the second diagnostic symptom of autism, communication deficits. As compared to the commonly used C57BL/6J (B6) strain, BTBR pups called more loudly and more frequently when separated from their mothers and siblings. Detailed analysis of ten categories of calls revealed an unusual pattern in BTBR as compared to B6. BTBR emitted high levels of harmonics, two-syllable, and composite calls, but minimal numbers of chevron-shaped syllables, upward, downward, and short calls. Because body weights were higher in BTBR than B6 pups, one possible explanation was that larger thoracic size was responsible for the louder calls and different distribution of syllable categories. To test this possibility, we recorded separation calls from FVB/NJ, a strain with body weights similar to BTBR, and 129X1/SvJ, a strain with body weights similar to B6. BTBR remained the outlier on number of calls, displaying low numbers of complex, upward, chevron, short, and frequency steps calls, along with high harmonics and composites. Further, developmental milestones and growth rates were accelerated in BTBR, indicating an unusual neurodevelopmental trajectory. Overall, our findings demonstrate strain-specific patterns of ultrasonic calls that may represent different lexicons, or innate variations in complex vocal repertoires, in genetically distinct strains of mice. Particularly intriguing is the unusual pattern of vocalizations and the more frequent, loud harmonics evident in the BTBR mouse model of autism that may resemble the atypical vocalizations seen in some autistic infants.
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DOI：
10.1007/s00359-005-0036-y
发表时间：
2005-12-01
影响因子：
2.1
作者：
Gaub, S;Ehret, G
通讯作者：
Ehret, G
影响因子：
8.2
作者：
Branchi, I;Bichler, Z;Ricceri, L
通讯作者：
Ricceri, L
影响因子：
2.6
作者：
Brudzynski, SM
通讯作者：
Brudzynski, SM
影响因子：
64.8
作者：
EHRET, G
通讯作者：
EHRET, G
影响因子：
2.7
作者：
BROUETTELAHLOU, I;VERNETMAURY, E;VIGOUROUX, M
通讯作者：
VIGOUROUX, M