Aldosterone secretion by the mid-gestation ovine fetus: role of the AT2 receptor
Aldosterone secretion by the mid-gestation ovine fetus: role of the AT2 receptor
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DOI：
10.1016/s0303-7207(99)00148-3
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发表时间：
1999-11
影响因子：
4.1
通讯作者：
K. Moritz;W. Boon;E. Wintour
中科院分区：
文献类型：
--
作者：
K. Moritz;W. Boon;E. Wintour
This study shows a short-term (3 h) infusion of ACTH but not angiotensin II (Ang II) stimulates aldosterone production in the mid-gestation fetus. No synergistic effect between ACTH and Ang II was observed. The fetal response was significantly less than observed in the adult animal when infused in a similar manner. Interestingly, plasma aldosterone could be stimulated by Ang II in the presence of a specific AT2receptor blocker. This suggests that the inability of Ang II to stimulate aldosterone may be due in part to Ang II binding to the AT2receptor and limiting the amount of available Ang II and/or antagonising the effects of Ang II on the AT1receptor.
