EXPERIENCE OF STANFORD NEUROMODULATION THERAPY IN PATIENTS WITH TREATMENT-RESISTANT DEPRESSION
EXPERIENCE OF STANFORD NEUROMODULATION THERAPY IN PATIENTS WITH TREATMENT-RESISTANT DEPRESSION
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DOI：
10.24075/brsmu.2022.044
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发表时间：
2022-07-01
影响因子：
0.2
通讯作者：
Piradov, M. A.
中科院分区：
文献类型：
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作者：
Poydasheva, A. G.;Bakulin, I. S.;Piradov, M. A.
斯坦福神经调节疗法（SNT）是最先进的磁刺激方案，已开发用于治疗难治性抑郁症（TRD）。该研究旨在评估SNT在临床实践中实施的可能性，并在独立中心确定TRD患者作为复发性抑郁症或双相情感障碍发作的方案的安全性和有效性。该研究涉及6例伴有复发性抑郁症和1型或2型双相情感障碍的TRD患者（其中3例年龄在21-66岁之间）。患者按照SNT方案接受了为期5天的间歇性θ -burst刺激：在与左背外侧前额叶皮层内的亚膝扣带皮层具有最大负功能连接的选定刺激部位，每天10次三次刺激，每次间隔1小时。采用Montgomery-Asberg抑郁评定量表（MADRS）进行临床疗效评估，随访3个月。在5名患者（MADRS评分）中，观察到SNT完成后抑郁症状立即改善到缓解的特征水平
Stanford neuromodulation therapy (SNT) is the state-of-the-art magnetic stimulation protocol that has been developed for management of treatment-resistant depression (TRD). The study was aimed to assess the possibility of SNT implementation in clinical practice and to define the protocol safety and efficacy in patients with TRD being an episode of the recurrent depressive disorder or bipolar disorder at the independent center. The study involved six patients (among them three women aged 21-66) with TRD associated with recurrent depression and type 1 or 2 bipolar disorder. The patients received intermittent theta-burst stimulation in accordance with the SNT protocol for five days: applying 10 triple blocks of stimulation daily at intervals of 1 hr between the blocks to the selected stimulation site showing maximum negative functional connectivity with subgenual cingulate cortex within the left dorsolateral prefrontal cortex. The Montgomery-Asberg Depression Rating Scale (MADRS) was used for clinical assessment of the effects, the follow-up period was three months. The improvement of depressive symptoms to the levels characteristic of remission immediately after the SNT completion was observed in five patients (MADRS score