Second Messenger Networks for Accurate Growth Cone Guidance
Second Messenger Networks for Accurate Growth Cone Guidance
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DOI：
10.1002/dneu.22157
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发表时间：
2015-04-01
影响因子：
3
通讯作者：
Kamiguchi, Hiroyuki
中科院分区：
文献类型：
--
作者：
Akiyama, Hiroki;Kamiguchi, Hiroyuki
生长锥能够通过遵循通常以细胞外梯度的形式呈现给它们的引导线索来长距离导航以找到它们适当的目标。这些外部信号被转化为生长锥内特定信号分子的梯度，同时这些内部信号被放大。然后使用放大的指令来在生长锥转动机械中产生不对称的变化，使得生长锥的一侧以比另一侧更快的速率移动，并且因此生长锥朝向或远离外部提示转动。这篇综述探讨了如何在生长锥内通过多个第二信使信号传导途径激活下游的指导线索来实现信号的规范和放大。这些包括钙离子、环核苷酸和磷脂酰肌醇信号通路。(c)2013 Wiley Periodicals，Inc.开发神经生物学75：411-422，2015年
Growth cones are able to navigate over long distances to find their appropriate target by following guidance cues that are often presented to them in the form of an extracellular gradient. These external cues are converted into gradients of specific signaling molecules inside growth cones, while at the same time these internal signals are amplified. The amplified instruction is then used to generate asymmetric changes in the growth cone turning machinery so that one side of the growth cone migrates at a rate faster than the other side, and thus the growth cone turns toward or away from the external cue. This review examines how signal specification and amplification can be achieved inside the growth cone by multiple second messenger signaling pathways activated downstream of guidance cues. These include the calcium ion, cyclic nucleotide, and phosphatidylinositol signaling pathways. (c) 2013 Wiley Periodicals, Inc. Develop Neurobiol 75: 411-422, 2015