A Wearable Electrochemical Platform for Noninvasive Simultaneous Monitoring of Ca2+ and pH
A Wearable Electrochemical Platform for Noninvasive Simultaneous Monitoring of Ca2+ and pH
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DOI：
10.1021/acsnano.6b04005
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发表时间：
2016-07-01
期刊：
影响因子：
17.1
通讯作者：
Javey, Ali
中科院分区：
文献类型：
--
作者：
Nyein, Hnin Yin Yin;Gao, Wei;Javey, Ali
生物流体中离子钙的稳态对于人类生物学功能和器官系统至关重要。由于其严格的程序和对pH的依赖性，无法轻易地对临床应用的电离钙进行测量。体液的pH平衡极大地影响了代谢反应和生物运输系统。在这里，我们展示了一种可穿戴的电化学装置，用于使用CA2+的可式和柔性阵列连续监测体液的离子化钙和pH值，并将其与灵活的印刷电路板连接在一起。该平台可以实时定量分析体液中的这些感应元素，例如汗水，尿液和眼泪。通过电感耦合的等离子体质谱技术和商用pH值，通过可穿戴传感器测量的Ca2+浓度和pH的精度得到了验证。我们的结果表明，可穿戴传感器对目标离子具有很高的可重复性和选择性。还进行了实时的体内汗液评估，我们的结果表明钙浓度随pH的降低而增加。该平台可用于体液中的电离钙和pH的无创分析，用于疾病诊断，例如原发性甲状旁腺功能亢进和肾结石。
Homeostasis of ionized calcium in biofluids is critical for human biological functions and organ systems. Measurement of ionized calcium for clinical applications is not easily accessible due to its strict procedures and dependence on pH. pH balance in body fluids greatly affects metabolic reactions and biological transport systems. Here, we demonstrate a wearable electrochemical device for continuous monitoring of ionized calcium and pH of body fluids using a disposable and flexible array of Ca2+ and pH sensors that interfaces with a flexible printed circuit board. This platform enables real-time quantitative analysis of these sensing elements in body fluids such as sweat, urine, and tears. Accuracy of Ca2+ concentration and pH measured by the wearable sensors is validated through inductively coupled plasma-mass spectrometry technique and a commercial pH meter, respectively. Our results show that the wearable sensors have high repeatability and selectivity to the target ions. Real-time on-body assessment of sweat is also performed, and our results indicate that calcium concentration increases with decreasing pH. This platform can be used in noninvasive continuous analysis of ionized calcium and pH in body fluids for disease diagnosis such as primary hyperparathyroidism and kidney stones.