Defining visual illusions in Parkinson's disease: Kinetopsia and object misidentification illusions
Defining visual illusions in Parkinson's disease: Kinetopsia and object misidentification illusions
复制标题
DOI：
10.1016/j.parkreldis.2018.05.023
复制
发表时间：
2018-10-01
影响因子：
4.1
通讯作者：
Mori, Etsuro
中科院分区：
文献类型：
--
作者：
Nishio, Yoshiyuki;Yokoi, Kayoko;Mori, Etsuro
目的：探讨帕金森病视错觉的现象学特征及相关神经机制。方法：对93例PD患者进行视错觉、行为症状问卷调查、神经心理测试、运动评估和18-F氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）。采用偏最小二乘（PLS）相关和传统的质量-单变量分析研究视错觉或幻觉与区域脑葡萄糖代谢的关系。结果：视错觉中最常见的两种类型分别是视错觉和视错觉，前者认为静止的物体是运动的，后者认为物体是不同的物体。运动斜视24例（25.8%），物体误认错觉17例（18.3%）。运动失视11例，物体误认错觉9例。运动缺失和视觉幻觉与颞顶叶皮层代谢低下有关，而物体误认错觉与早期视觉皮层和颞顶叶皮层代谢低下有关。结论：我们的研究结果表明，运动失视和物体错认错觉是PD患者最常见的视错觉类型。尽管PD患者的视错觉和幻觉在现象学上存在差异，但所有这些症状都与支持视觉空间处理的颞顶叶皮质功能障碍有关，而与支持视觉物体识别的腹侧颞枕叶皮质功能障碍无关。
Objective: To identify the phenomenological features and neural correlates of visual illusions in Parkinson's disease (PD).Methods: Ninety-three patients with PD were assessed via questionnaires regarding visual illusions and behavioral symptoms, and neuropsychological tests, motor assessments and 18-F fluorodeoxyglucose-positron emission tomography (FDG-PET) were performed. The relationship between visual illusions or hallucinations and regional cerebral glucose metabolism was investigated using partial least squares (PLS) correlation and conventional mass-univariate analyses.Results: Kinetopsia, in which stationary objects are perceived as being in motion, and object misidentification illusions, in which objects are misperceived as different objects, were the most common types of visual illusions. Kinetopsia and object misidentification illusions were identified in 24 patients (25.8%) and 17 patients (18.3%), respectively. Eleven patients with kinetopsia and 9 patients with object misidentification illusions had visual hallucinations. Kinetopsia and visual hallucinations were associated with hypometabolism in the temporoparietal cortices, whereas object misidentification illusions were associated with hypometabolism in the early visual cortex, as well as the temporo-parietal cortices.Conclusions: Our findings suggest that kinetopsia and object misidentification illusions are the most common types of visual illusions in PD. Despite the phenomenological diversity of visual illusions and hallucinations in PD, all of these symptoms are associated with dysfunction of the temporo-parietal cortices, which support visual spatial processing, rather than dysfunction of the ventral temporo-occipital cortices, which supports visual object recognition.