Effect of primary prophylaxis with pegfilgrastim in endometrial cancer patients treated with doxorubicin and cisplatin
Effect of primary prophylaxis with pegfilgrastim in endometrial cancer patients treated with doxorubicin and cisplatin
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聚乙二醇非格司亭一级预防对接受阿霉素和顺铂治疗的子宫内膜癌患者的影响
DOI：
10.1016/j.tjog.2022.02.013
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发表时间：
2022
影响因子：
2.1
通讯作者：
Osuga Yutaka
中科院分区：
文献类型：
--
作者：
Tojima Yuri;Taguchi Ayumi;Mori Mayuyo;Nara Katsuhiko;Miyamoto Yuichiro;Tanikawa Michihiro;Sone Kenbun;Tsuruga Tetsushi;Yamamoto Takehito;Oda Katsutoshi;Suzuki Hiroshi;Osuga Yutaka
虽然发热性中性粒细胞减少症（FN）的发生率是相对较高的阿霉素和顺铂联合方案比其他方案在子宫内膜癌，证据培非格司亭在此方案的疗效是缺乏的Materials MethodsWe回顾性分析了58例子宫内膜癌患者的资料谁是阿霉素加顺铂治疗。将患者分为一级预防组和非预防组。我们比较了FN和中性粒细胞减少症的发生率以及化疗相对剂量强度（RDI）和抗生素的使用率between groups.ResultsThe FN（8.0%vs.34.8%）和4级中性粒细胞减少症（12.0%vs.87.0%）的发生率在一级预防组显著降低。虽然有组之间的RDI没有差异，初级预防组有较低的抗生素prescription.ConclusionPreventive率与培非格司亭有效地防止FN的阿霉素和顺铂治疗的患者。
ObjectiveAlthough the incidence of febrile neutropenia (FN) is relatively higher for doxorubicin and cisplatin combination regimen than for other regimens in endometrial cancer, evidence regarding the efficacy of pegfilgrastim in this regimen is lacking.Materials and methodsWe retrospectively reviewed the data of 58 patients with endometrial cancer who were treated with doxorubicin plus cisplatin. The patients were divided into primary prophylaxis and non-prophylaxis groups. We compared the incidence of FN and neutropenia as well as the chemotherapy relative dose intensity (RDI) and usage of antibiotics between the groups.ResultsThe rates of FN (8.0% vs. 34.8%) and grade 4 neutropenia (12.0% vs. 87.0%) were significantly lower in the primary prophylaxis group. Although there was no difference in the RDI between the groups, the primary prophylaxis group had a lower rate of antibiotic prescriptions.ConclusionProphylaxis with pegfilgrastim efficiently prevented FN in patients treated with doxorubicin and cisplatin.