Dopaminergic Circuitry Underlying Mating Drive
Dopaminergic Circuitry Underlying Mating Drive
复制标题
DOI：
10.1016/j.neuron.2016.05.020
复制
发表时间：
2016-07
期刊：
影响因子：
16.2
通讯作者：
Stephen X. Zhang;Dragana Rogulja;Michael A. Crickmore
中科院分区：
文献类型：
--
作者：
Stephen X. Zhang;Dragana Rogulja;Michael A. Crickmore
我们开发了一个新的系统，用于研究先天驱动如何调整以反映当前的生理需求和能力，以及它们如何影响感觉运动处理。我们证明了果蝇中存在雄性交配驱力，这种驱力随着交配消耗生殖能力而短暂地和累积地降低。多巴胺能活动的前部的上级内侧前脑（SMPA）也短暂和累积减少交配的反应，并作为一个功能性神经元相关的交配驱动。多巴胺信号通过D1样DopR2受体传递到P1神经元，P1神经元也整合与雌性感知相关的感觉信息，并投射到启动和维持求偶行为的求偶运动中心。因此，在向运动输出的过渡点上，交配驱力与来自雌性的感觉信息相融合，控制着感觉冲动触发目标导向行为的倾向。
We develop a new system for studying how innate drives are tuned to reflect current physiological needs and capacities, and how they affect sensory-motor processing. We demonstrate the existence of male mating drive inDrosophila, which is transiently and cumulatively reduced as reproductive capacity is depleted by copulations. Dopaminergic activity in the anterior of the superior medial protocerebrum (SMPa) is also transiently and cumulatively reduced in response to matings and serves as a functional neuronal correlate of mating drive. The dopamine signal is transmitted through the D1-like DopR2 receptor to P1 neurons, which also integrate sensory information relevant to the perception of females, and which project to courtship motor centers that initiate and maintain courtship behavior. Mating drive therefore converges with sensory information from the female at the point of transition to motor output, controlling the propensity of a sensory percept to trigger goal-directed behavior.