B-cell-activating factor belonging to the tumor necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL) levels in cerebrospinal fluid of patients with meningoencephalitis
B-cell-activating factor belonging to the tumor necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL) levels in cerebrospinal fluid of patients with meningoencephalitis
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DOI：
10.1016/j.jns.2015.03.036
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发表时间：
2015-05-15
影响因子：
4.4
通讯作者：
Hayashi, Yuichi
中科院分区：
文献类型：
--
作者：
Kimura, Akio;Yoshikura, Nobuaki;Hayashi, Yuichi
肿瘤坏死因子家族(BAFF)中的B细胞激活因子(BAFF)和增殖诱导配体(APRIL)是过渡期和成熟期B细胞存活的重要因素。患有几种自身免疫性疾病的成年人中存在高水平的BAFF和APRIL。然而，有关脑膜脑炎患者脑脊液中BAFF和APRIL水平的报道很少。我们检测了病毒性脑膜炎(VM)(28例)、自身免疫性脑炎(AE)伴抗神经元抗体(15例)、特发性正常压力性脑积水(INPH)(11例)、单纯疱疹病毒性脑炎(HSE)(9例)、细菌性脑膜炎(BM)(6例)和隐球菌性脑膜炎(CM)(4例)患者脑脊液中BAFF和APRIL的水平。HSE、BM或VM患者的脑脊液BAFF水平显著高于AE或INPH患者，CM患者的脑脊液BAFF水平显著高于INPH患者。HSE或BM患者的CSFAPRIL水平显著高于AE、VM或INPH患者。虽然这是一个初步报告，由于组内差异和样本量较小，但数据表明HSE和BM的脑脊液BAFF和APRIL水平增加，但AE没有增加。(C)2015爱思唯尔B.V.保留所有权利。
The B-cell-activating factor belonging to the tumor necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL) are important factors for the survival of transitional and mature B cells. High levels of BAFF and APRIL are present in adults with several autoimmune diseases. However, there are few reports about BAFF and APRIL levels in the cerebrospinal fluid (CSF) of patients with meningoencephalitis. We evaluated BAFF and APRIL levels in CSF samples from patients with viral meningitis (VM) (28 patients), autoimmune encephalitis (AE) associated with antineuronal antibodies (15 patients), idiopathic normal pressure hydrocephalus (iNPH) (11 patients), herpes simplex encephalitis (HSE) (9 patients), bacterial meningitis (BM) (6 patients), and cryptococcal meningitis (CM) (4 patients). The CSF BAFF levels were significantly higher in patients with HSE, BM, or VM than AE or iNPH, and significantly higher in patients with CM than iNPH. The CSF APRIL levels were significantly higher in patients with HSE or BM than AE, VM, or iNPH. Although this is a preliminary report due to within-group variation and small sample size, the data suggest that CSF BAFF and APRIL levels are increased in HSE and BM, but not AE. (C) 2015 Elsevier B.V. All rights reserved.