The Role of Parkin in Familial and Sporadic Parkinson's Disease
The Role of Parkin in Familial and Sporadic Parkinson's Disease
复制标题
DOI：
10.1002/mds.22798
复制
发表时间：
2010-01-01
影响因子：
8.6
通讯作者：
Dawson, Valina L.
中科院分区：
文献类型：
--
作者：
Dawson, Ted M.;Dawson, Valina L.
帕金突变是帕金森病（PD）的第二大已知原因。帕金蛋白是一种泛素E3连接酶，其单泛素化和多泛素化蛋白质以调节多种细胞过程。帕金E3连接酶活性的丧失被认为在遗传性和散发性PD中起致病作用。本文就帕金森病的生物学、病理学及其在帕金森病发病机制中的作用作一综述。(C)2010年运动障碍协会
Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic role in both inherited and sporadic PD. Here, we review parkin biology and pathobiology and its role in the pathogenesis of PD. (C) 2010 Movement Disorder Society