2-(2-Phenylethyl)chromone derivatives: Promising α-glucosidase inhibitors in agarwood from Aquilaria filaria
2-(2-Phenylethyl)chromone derivatives: Promising α-glucosidase inhibitors in agarwood from Aquilaria filaria
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DOI：
10.1016/j.phytochem.2020.112578
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发表时间：
2021-01-01
期刊：
影响因子：
3.8
通讯作者：
Dai, Hao-fu
中科院分区：
文献类型：
--
作者：
Mi, Cheng-neng;Yuan, Jing-zhe;Dai, Hao-fu
从白木香的乙酸乙酯萃取物中分离得到12个未描述的2-（2-苯乙基）色酮衍生物，其中包括1对映体和11个已知的2-（2-苯乙基）色酮衍生物。所有化合物的结构均经波谱（NMR，UV，IR，MS）确证，并与文献报道的数据进行了比较。评估了21种化合物的α-葡糖苷酶抑制活性，其显示出对α-葡糖苷酶的抑制，IC 50值范围为7.8 +/- 0.3至137.7 +/- 3.0 μ M（阿卡波糖，743.4 +/- 3.3 μ M;染料木素，8.3 +/- 0.1 μ M）。我们的研究结果扩展了沉香中2-（2-苯乙基）色酮的结构多样性，并揭示了2-（2-苯乙基）色酮作为α-葡萄糖苷酶抑制剂的潜力。
Twelve undescribed 2-(2-phenylethyl)chromone derivatives, including one pair of enantiomers, together with eleven known ones, were isolated from the EtOAc extract of agarwood originating from Aquilaria filaria. All structures were elucidated by spectroscopic (NMR, UV, IR, MS) methods and compared with reported data in literatures. Twenty-one compounds were assessed for alpha-glucosidase inhibitory activity, which showed inhibition of alpha-glucosidase with IC50 values ranging between 7.8 +/- 0.3 to 137.7 +/- 3.0 mu M (Acarbose, 743.4 +/- 3.3 mu M; Genistein, 8.3 +/- 0.1 mu M). Our results expanded the structural diversity of 2-(2-phenylethyl)chromones from agarwood, and revealed the potential of 2-(2-phenylethyl)chromones as alpha-glucosidase inhibitors.