Potentiation of toluene toxicity by hepatic enzyme inhibition in mice.
Potentiation of toluene toxicity by hepatic enzyme inhibition in mice.
复制标题
通过抑制小鼠肝酶来增强甲苯毒性。
DOI：
10.2131/jts.3.25
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
Y. Ohmiya
中科院分区：
文献类型：
--
作者：
K. Koga;Y. Ohmiya
通过麻醉作用和致死率评价甲苯对雄性小鼠的毒性。按Weil法计算出甲苯对雄性小鼠的腹腔LD_（50）为1.15g/kg。用苯巴比妥预处理，产生由测试剂量（0.96 g/kg i. p.）甲苯。与此相反，预处理与各种肝酶抑制剂，如四氯化碳，SKF 525 A，吡唑和氰胺被发现产生的睡眠和死亡的数量增加，伴随着睡眠时间的延长。目前的结果表明，甲苯的毒性是通过抑制代谢的任何步骤而增强的。
The toxicity of toluene was evaluated in male mice by the narcotic effects and lethality. The i.p. LD50 of toluene for male mice was calculated to be 1.15g/kg according to the method of Weil. Pretreatment with phenobarbital, produced a marked decrease in the number of sleep induced by a test dose (0.96 g/kg i.p.) of toluene. By contrast, pretreatment with a variety of hepatic enzyme inhibitors such as CCl4, SKF 525A, pyrazole and cyanamide was found to produce an increase in the number of sleep and death, accompanied with the prolongation of sleeping time. The present results suggest that the toxicity of toluene is enhanced by the inhibition of any step of metabolism.