Mechanics of cytokinesis in eukaryotes.

Mechanics of cytokinesis in eukaryotes.
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DOI:
10.1016/j.ceb.2009.11.010
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发表时间:
2010-02
影响因子:
7.5
通讯作者:
Pollard TD
Pollard TD
中科院分区:
生物学2区
文献类型:
--
作者:
Pollard TD

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使用有利的模型系统对真核细胞胞质分裂的研究正在迅速推进我们对该过程的大多数方面的理解。胞质分裂非常复杂,有100多种蛋白质参与。真菌和动物细胞都使用蛋白质来标记肌动蛋白丝和肌球蛋白II的收缩环组装的切割位点。形成蛋白使肌动蛋白丝成核并伸长,肌球蛋白-II有助于将肌动蛋白丝组织成收缩环。关于收缩环的组织结构和收缩时分解收缩环的机制,还有很多东西需要了解。虽然真菌和动物共享许多有助于胞质分裂的蛋白质,但它们在收缩环的定位、组装、收缩和分解方面共享机制的程度仍然存在疑问。
Research on eukaryotic cytokinesis using advantageous model systems is rapidly advancing our understanding of most aspects of the process. Cytokinesis is very complicated with more than 100 proteins participating. Both fungi and animal cells use proteins to mark the cleavage site for the assembly of a contractile ring of actin filaments and myosin-II. Formins nucleate and elongate the actin filaments and myosin-II helps to organize the filaments into a contractile ring. Much is still to be learned about the organization of the contractile ring and the mechanisms that disassemble the ring as it constricts. Although fungi and animals share many proteins that contribute to cytokinesis, the extent to which they share mechanisms for the location, assembly, constriction, and disassembly of their contractile rings is still in question.
靶向细胞分裂部位靶向萌芽酵母肌球蛋白II所需的最小结构域的表征。
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