Origin of genes
Origin of genes
复制标题
DOI：
10.1073/pnas.94.15.7698
复制
发表时间：
1997-07-22
影响因子：
11.1
通讯作者：
Long, MY
中科院分区：
文献类型：
--
作者：
Gilbert, W;deSouza, SJ;Long, MY
我们讨论了第一个基因crc由外显子重组的假设的两个检验。前代基因中外显子改组的假设预测了内含子的相位将是相关的，从而外显子将是整数个密码子，并预测外显子将与多肽链的紧凑区相关，这些预测已经在古老的保守蛋白质（原核生物中没有内含子的蛋白质，而真核生物中有内含子的蛋白质）上进行了测试，并具有很高的统计学意义。我们的结论是，内含子与15-，22-或30-氨基酸残基长的蛋白质的计算机特征相关，正如“基因外显子理论”所预测的那样。''
We discuss two tests of the hypothesis that the first genes crc re assembled from exons, The hypothesis of exon shuffling in the progenote predicts that intron phases will be correlated so that exons will be an integer number of codons and predicts that the exons will he correlated with compact regions of polypeptide chain, These predictions have been tested on ancient conserved proteins (proteins without introns in prokaryotes hut with introns in eukaryotes) and hold with high statistical significance. We conclude that introns are correlated with computer features of proteins 15-, 22-, or 30-amino acid residues long, as was predicted by ''The Exon Theory of Genes.''