Modulation of DNA Binding by Reversible Metal-Controlled Molecular Reorganizations of Scorpiand-like Ligands
Modulation of DNA Binding by Reversible Metal-Controlled Molecular Reorganizations of Scorpiand-like Ligands
复制标题
DOI：
10.1021/ja300538s
复制
发表时间：
2012-06-13
影响因子：
15
通讯作者：
Garcia-Espana, Enrique
中科院分区：
文献类型：
--
作者：
Inclan, Mario;Teresa Albelda, M.;Garcia-Espana, Enrique
DNA与蝎子和氮杂大环的相互作用是通过调节它们的结合亲和力来实现的。用不同的实验技术进行的研究提供了证据，表明这些配体的pH或金属驱动的分子重组调控它们通过嵌入模式与小牛胸腺DNA(CtDNA)相互作用的能力。有趣的是，金属驱动的分子重组有助于显著增加或降低这些化合物的生物活性。
DNA interaction with scorpiand azamacrocycles has been achieved through modulation of their binding affinities. Studies performed with different experimental techniques provided evidence that pH or metal-driven molecular reorganizations of these ligands regulate their ability to interact with calf thymus DNA (ctDNA) through an intercalative mode. Interestingly enough, metal-driven molecular reorganizations serve to increase or decrease the biological activities of these compounds significantly.